155306-M
AMPA Agonist, CMPA
The AMPA Agonist, CMPA controls the biological activity of AMPA. This small molecule/inhibitor is primarily used for Biochemicals applications.
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Synonym(s):
AMPA Agonist, CMPA, N,Nʹ-(2,2ʹ-(1,4-phenylene)bis(ethane-2,1-diyl))dipropane-2-sulfonamide, AMPA Activator
Empirical Formula (Hill Notation):
C16H28N2O4S2
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
solution
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
clear almost colorless
off-white
solubility
DMSO: 100 mg/mL
storage temp.
2-8°C
SMILES string
CC(C)S(=O)(=O)NCCC1=CC=C(C=C1)CCNS(=O)(=O)C(C)C
General description
A bisalykylsulfonamide that acts as a positive, allosteric modulator against AMPA receptors (EC50 = 45 nM and 63 nM for GluA2i and GluA2o, respectively) in a HEK 293 calcium FLIPR assay. At 10 µM, it robustly modulates receptor desensitization of both the flip (GluA2i) and flop (GluA2o) isoforms of GluA2 receptors in transfected HEK 293 cells with higher potency and efficacy than two other distinct AMPA modulators, cyclothiazide and CX614. Using a ligand bound crystal structure, it is shown to bind to the dimer interface of the extracellular ligand-binding domain of AMPA receptors, a region that partially overlaps with binding pockets for cyclothiazide and CX614.
The AMPA Agonist, CMPA controls the biological activity of AMPA. This small molecule/inhibitor is primarily used for Biochemicals applications.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Timm, D., et al. 2011. Mol. Pharm.80, 267.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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