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14-721-M

Sigma-Aldrich

EGFR (T790M, L858R) Protein, active, 10 µg

Active, N-terminal GST-tagged, recombinant human EGFR, amino acids 696-end containing the mutations T790M & L858R, for use in Enzyme Assays.

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About This Item

UNSPSC Code:
12352202
eCl@ss:
32160405
NACRES:
NA.32

biological source

human

Quality Level

100

recombinant

expressed in baculovirus infected Sf21 cells

product line

Upstate®

specific activity

(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)

mol wt

Mw 85.8 kDa

purified by

(Glutathione-agarose)

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable

accession no.

 (FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist. )
NM_005228.3

NCBI accession no.

NM_005228.3
NM_201282.1
NM_201283.1
NM_201284.1

UniProt accession no.

P00533

relevant disease(s)

arthritis; obesity; osteoporosis; metabolic disorders

General description

N-terminal GST-tagged, recombinant human EGFR, amino acids 696end containing the mutations T790M and L858R

Application

Research Category
Metabolism

Inflammation & Immunology
Research Sub Category
Obesity

Metabolic Disorders

Osteoporosis

Arthritis

Biochem/physiol Actions

Protein Target: EGFR
Target Sub-Family: TK

Packaging

Also available in 10 μg size and in bulk

Quality

routinely evaluated by phosphorylation of 250μM substrate peptide (GGMEDIYFEFMGGKKK)

Target description

EGFR

Physical form

Glutathione-agarose

Storage and Stability

6 months at -70°C from date of shipment

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Hazard Classifications

Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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