14-628-M
TBK1 Protein, active, 10 µg
Active, N-terminal His6-tagged, recombinant, full length, human TBK1, for use in Kinase Assays.
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Synonym(s):
NAK, NF-kappa-B-activating kinase, T2K, TANK-binding kinase-1
UNSPSC Code:
12352200
eCl@ss:
32160405
NACRES:
NA.32
Recommended Products
biological source
human
Quality Level
recombinant
expressed in baculovirus infected Sf21 cells
shelf life
6 mo.
mol wt
Mw 85.7 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (kinase)
NCBI accession no.
UniProt accession no.
storage temp.
−70°C
Gene Information
human ... TBK1(29110)
General description
Research area: Cancer
Protein Target: TBK1, Target Sub-Family: Misc
TANK-binding kinase-1 (TBK1), also known as NF-κB activating kinase (NAK), is a serine-threonine kinase from the IκB kinase (IKK) family. It is encoded by tbk1 gene and is ubiquitously expressed in various tissues.
Protein Target: TBK1, Target Sub-Family: Misc
TANK-binding kinase-1 (TBK1), also known as NF-κB activating kinase (NAK), is a serine-threonine kinase from the IκB kinase (IKK) family. It is encoded by tbk1 gene and is ubiquitously expressed in various tissues.
Application
Research Category
Inflammation & Immunology
Inflammation & Immunology
Biochem/physiol Actions
TANK-binding kinase-1 (TBK1) is mainly involved in activating interferon regulatory transcription factor 3/7 (IRF 3/7) and nuclear factor (NF-κB) signaling pathways, which are essential for regulating the production of type I interferons (IFN), including IFN-α and IFN-β and the activation of innate immunity. In addition, TBK1 also mediates various other cellular processes including autophagy, proliferation, immune response/inflammation survival, insulin signaling, and metabolism. TBK1 plays a significant role in cancer pathogenesis. In cancer cells, it enhances tumor growth by activating proliferation and survival signaling, promoting tumor-promoting cytokine production, and facilitating the secretion of immunosuppressive inflammatory cytokines. Overexpression of tbk1 gene is observed in various cancers including non-small cell lung cancer (NSCLC), pancreatic ductal adenocarcinoma (PDA), cholangiocarcinoma, clear cell renal cell carcinoma (ccRCC), adult T-cell leukemia, melanoma, esophageal cancer, and breast cancer.
Quality
routinely evaluated by phosphorylation of CK1tide (12-529)
Physical form
Ni2+/NTA-agarose
Storage and Stability
6 months at -70°C
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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André Richters et al.
ACS chemical biology, 10(1), 289-298 (2014-12-30)
The cytosolic Ser/Thr kinase TBK1 was discovered to be an essential element in the mediation of signals that lead to tumor migration and progression. These findings meet the need for the identification of novel tool compounds and potential therapeutics to
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