14-595-M
PP1α Protein, 10 µg
Recombinant, full length, human PP1α, for use in Phosphatase Assays.
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UNSPSC Code:
12352200
eCl@ss:
32160405
NACRES:
NA.32
Recommended Products
biological source
human
Quality Level
recombinant
expressed in E. coli
mol wt
Mw 37.6 kDa
manufacturer/tradename
Upstate®
technique(s)
activity assay: suitable (phosphatase)
NCBI accession no.
UniProt accession no.
Gene Information
human ... PPP1CA(5499)
General description
Product Source: expressed in E. coli cells
recombinant, full length, human PP1α
Application
Research Category
Inflammation & Immunology
Inflammation & Immunology
Biochem/physiol Actions
Protein Target: PP1α
Target Sub-Family: Ser/Thr phosphatase
Packaging
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-595M when ordering the 250 µg size.
Quality
routinely evaluated by dephosphorylation of 100μM DiFMUP
Physical form
Heparin agarose followed by Q agarose
Storage and Stability
6 months at -20°C from date of shipment
Other Notes
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Skin Sens. 1
WGK
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Modulation of dendritic spines by protein phosphatase-1
Advances in Pharmacology, 90.0, 117-144 (2021)
The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity.
Munton, Richard P, et al.
Febs Letters, 567, 121-128 (2004)
Alphonse Garcia et al.
Biochimie, 85(8), 721-726 (2003-10-31)
The reversible phosphorylation of proteins controlled by protein kinases and protein phosphatases is a major mechanism that regulates a wide variety of cellular processes. In contrast to C. elegans, recent studies in mammalian cells have highlighted a major role of
Karl Foley et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(14), 3040-3050 (2021-04-09)
Protein phosphatases, by counteracting protein kinases, regulate the reversible phosphorylation of many substrates involved in synaptic plasticity, a cellular model for learning and memory. A prominent phosphatase regulating synaptic plasticity and neurologic disorders is the serine/threonine protein phosphatase 1 (PP1).
Patricia T W Cohen
Journal of cell science, 115(Pt 2), 241-256 (2002-02-13)
Protein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase that regulates an enormous variety of cellular functions through the interaction of its catalytic subunit (PP1c) with over fifty different established or putative regulatory subunits. Most of these target
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