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1.37003

Citric acid monohydrate

Name: Citric acid monohydrate
Brand: MM

crystalline, EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

Pharma Manufacturing

Synonym(s):

2-Hydroxypropane-1,2,3-tricarboxylic acid, Hydroxytricarballylic acid

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About This Item

Linear Formula:

HOC(COOH)(CH₂COOH)₂ · H₂O

CAS Number:

5949-29-1

Molecular Weight:

210.14

Beilstein:

4018641

MDL number:

MFCD00149972

UNSPSC Code:

12352106

EC Index Number:

201-069-1

Agency

BP
ChP
JP
Ph. Eur.
USP

Quality Level

500

vapor pressure

<1 Pa ( 25 °C)

description

cryst. EMPROVE^® EXPERT Ph Eur,BP,ChP,JP,USP

product line

EMPROVE^® EXPERT

form

crystalline
solid

feature

RNase and DNase free

pH

1.85 (25 °C, 50 g/L in H₂O)

pKa

(1) 3.13, (2) 4.76, (3) 6.4

mp

135-152 °C

transition temp

flash point 173.9 °C

solubility

880 g/L

density

1.54 g/cm³ at 20 °C

application(s)

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

storage temp.

15-25°C

SMILES string

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

InChI key

YASYEJJMZJALEJ-UHFFFAOYSA-N

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Related Categories

Biopharmaceutical Formulation

Downstream Process & Formulation Chemicals

Excipients for Your Liquid Application

Injectables & Parenteral Formulations

Protein Stabilizers

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Citric acid anhydrous is typically used as a citrate buffer system component for biomolecule downstream chromatography steps or final liquid formulation.
Due to its low microbial and endotoxin limits, Citric acid anhydrous Emprove^® Expert is especially suitable for high-risk applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.

Description

Pricing

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H319,H335

Precautionary Statements

P261 - P264 - P271 - P280 - P304 + P340 + P312 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 1

Flash Point(F)

345.0 °F

Flash Point(C)

173.9 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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