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Sigma-Aldrich

CHKtide (CHK1/CHK2 substrate peptide)

CHKtide (CHK1/CHK2 substrate peptide) primarily used in Kinase Assays.

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About This Item

UNSPSC Code:
12352200
eCl@ss:
32160405
NACRES:
NA.41

Quality Level

manufacturer/tradename

Upstate®

technique(s)

activity assay: suitable (kinase)

NCBI accession no.

UniProt accession no.

shipped in

wet ice

Gene Information

human ... CHEK1(1111)

Biochem/physiol Actions

Protein Target: CHK
Target Sub-Family: CAMK

Quality

Routinely evaluated by Protein Kinase Assay as a substrate for the active CHK1 (Catalog #14-346) and CHK2 (Catalog #14-347) kinases.

Physical form

Lyophilized powder

Storage and Stability

Lyophilized: 2 years at 4°C; Rehydrated: 6 months at -20°C.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Hidemasa Oh et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(9), 5378-5383 (2003-04-19)
The "postmitotic" phenotype in adult cardiac muscle exhibits similarities to replicative senescence more generally and constitutes a barrier to effective restorative growth in heart disease. Telomere dysfunction is implicated in senescence and apoptotic signaling but its potential role in heart
B Furnari et al.
Science (New York, N.Y.), 277(5331), 1495-1497 (1997-09-05)
Arrest of the cell cycle at the G2 checkpoint, induced by DNA damage, requires inhibitory phosphorylation of the kinase Cdc2 in both fission yeast and human cells. The kinase Wee1 and the phosphatase Cdc25, which regulate Cdc2 phosphorylation, were evaluated
Y Sanchez et al.
Science (New York, N.Y.), 277(5331), 1497-1501 (1997-09-05)
In response to DNA damage, mammalian cells prevent cell cycle progression through the control of critical cell cycle regulators. A human gene was identified that encodes the protein Chk1, a homolog of the Schizosaccharomyces pombe Chk1 protein kinase, which is

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