1.16882
Fractogel® EMD SO3 ⁻ (M) Resin
Synonym(s):
Fractogel® EMD SO₃⁻ (M)
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About This Item
Recommended Products
Quality Level
ligand
(Sulfoisobutyl)
description
strong cation exchanger, suspension in 20% ethanol and 150 mM NaCl (40-90 µm)
sterility
sterile (Caustic Stable)
product line
Fractogel®
form
resin
specific analyte(s)
MAbs
parameter
8 bar max. pressure
matrix active group
methacrylate
mean particle size
40-90 μm
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This Item | 46827U | 46855U | CRM47543 |
|---|---|---|---|
| application(s) petroleum | application(s) environmental | application(s) environmental | application(s) environmental |
| grade certified reference material, TraceCERT® | grade certified reference material, TraceCERT® | grade certified reference material | grade certified reference material, TraceCERT® |
| product line TraceCERT® | product line TraceCERT® | product line - | product line TraceCERT® |
| CofA current certificate can be downloaded | CofA current certificate can be downloaded | CofA current certificate can be downloaded | CofA current certificate can be downloaded |
| packaging ampule of 1 mL | packaging ampule of 1 mL | packaging ampule of 1 mL | packaging ampule of 1 mL |
General description
Features and Benefits
- Increased binding strength at low pH
- High aggregate removal efficiency combined with high dynamic binding capacity
- Lower elution volumes for the highest purity levels
- Compatibility with 2.5 % (v/v) aqueous benzyl alcohol containing 150 mM NaCl storage solution
Due to the titration behavior, the ion exchange capacity can be used from pH 2 to pH 12. The separation of proteins is based on reversible electrostatic interactions between the surface′s positively charged regions and the support. Proteins are retained efficiently on Fractogel® EMD SO3- (M) when the pH of the buffer is about 1 unit below their isoelectric points (pl).
The strength of the binding depends on the following:
- the buffer system
- pH value of the buffer which determines the surface charge of the protein
- the concentration of the counter ions
- the charge density on the support (protein binding capacity)
Packaging
- 1.16882.0100: Fractogel® EMD SO3- (M) Resin 100ml
- 1.16882.0010: Fractogel® EMD SO3- (M) Resin 10ml
- 1.16880.0500: Fractogel® EMD SO3- (M) Resin 500ml
- 1.16882.5000: Fractogel® EMD SO3- (M) Resin 5L
Analysis Note
Microscopic evaluation: Uniform spherical particles,no agglomerates, no fines
Extractable matter (water): ≤ 0.05 %
Cerium: ≤ 1 µg/g
Pressure drop(column: ID=1.6 cm, L=10 cm at 5 ml/min): ≤ 1.0 bar
Particle size (d10): 37 - 45 µm
Particle size (d50): 48 - 60 µm
Particle size (d90): 63 - 77 µm
Colony forming units (TAMC + TYMC): ≤ 100 CFU/ml
Endotoxins: ≤ 1.00 EU/ml
Protein binding capacity (lysozyme): 110 - 150 mg/ml
Functional test (b:a): ≤ 0.4
Functional test (c:d): ≤ 0.45
Functional test: Separation chymotrypsinogen A, cytochrom C and lysozyme
Legal Information
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Flam. Liq. 3
Storage Class Code
3 - Flammable liquids
WGK
WGK 1
Flash Point(F)
95.0 °F
Flash Point(C)
35 °C
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