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Supelco

Superspher® 100 RP-18 endcapped (4µm) HPLC Columns

L x I.D. 125 mm x 4 mm, LiChroCART® HPLC cartridge, manuCART™ holder required for use

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Synonym(s):
TM=["Superspher"] C18 TM=["LICHROCART"] cartridge for HPLC
UNSPSC Code:
41115709
NACRES:
SB.52

product name

Superspher® 100 RP-18 endcapped LiChroCART® 125-4, suitable for HPLC

material

stainless steel column

Quality Level

100

Agency

suitable for USP L1

product line

Superspher®

feature

endcapped

parameter

250 bar pressure
60 °C max. temp.

technique(s)

HPLC: suitable
mass spectrometry (MS): suitable (Low - Medium)

column L × I.D.

12.5 cm × 4 mm

matrix

fully porous particle

matrix active group

C18 bonding phase

particle size

4 μm

pore size

100 Å pore size

operating pH range

2-7.5

separation technique

reversed phase

storage temp.

no temp limit

Related Categories

General description

HPLC cartridge
Superspher® RP-18 endcapped is a reliable and versatile traditionally produced spherical silica gel carriers with C-18 endcapped reversed phase properties. They are well suited for the separation of neutral, acidic and weak basic compounds. This high performance silica carrier with a particle size of 4µm yields an excellent pressure/separation performance ratio.This sorbent is packed into a LiChroCART 125-4 HPLC cartridge. The connection to the HPLC system is being accomplished by use of the manu-CART NT cartrige holder (1.51486).

Application


  • Chemometric approach for estimation of ropinirole hydrochloride: This study presents a chemometric approach for the development and validation of an HPLC method for estimating ropinirole hydrochloride using LiChrospher 100 RP-18 columns. The method shows robustness and efficiency for pharmaceutical analysis (Fatima et al., 2019).

  • Simultaneous quantification of Parkinson′s disease medications: An HPLC method using LiChrospher 100 RP-18 was validated for simultaneous quantification of levodopa, carbidopa, benserazide, and entacapone in complex matrices, proving its capability in pharmaceutical formulations (Wollmer & Klein, 2017).

  • Stability of THCA and (9)-THC in herbal cannabis: This research employed LiChrospher 100 RP-18 columns to determine the stability of THCA and Δ(9)-THC in herbal cannabis under different storage temperatures, important for forensic and pharmaceutical sciences (Taschwer & Schmid, 2015).

  • Stability indicating method for cilazapril: Researchers developed a rapid and simple stability-indicating HPLC method for cilazapril, using LiChrospher 100 RP-18, to assess drug stability in pharmaceuticals, compared to spectrophotometric methods, highlighting its precision and reliability (Paszun et al., 2012).


Analysis Note

Pressure: ≤ 80 bar
Theoretical Plates (N/m) (Anthracene): ≥ 100000
Symmetry (Anthracene): 0.8 - 1.4
Capacity factor (Anthracene): 3.5 - 5.5

Legal Information

LICHROCART is a registered trademark of Merck KGaA, Darmstadt, Germany
Superspher is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

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