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Merck
CN

1.08386

Tris(hydroxymethyl)aminomethane

(Trometamol), EMPROVE® EXPERT, Ph. Eur., BP, ChP, JPC, USP

Synonym(s):

Tromethamine, 2-Amino-2-(hydroxymethyl)-1,3-propanediol, THAM, Tris base, Trometamol

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About This Item

Linear Formula:
NH2C(CH2OH)3
CAS Number:
77-86-1
Molecular Weight:
121.14
EC Index Number:
201-064-4
UNSPSC Code:
12352104
Beilstein/REAXYS Number:
741883
MDL number:
MFCD00004679

Key Documents

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Product Name

Tris(hydroxymethyl)aminomethane, (Trometamol), EMPROVE® EXPERT, Ph. Eur., BP, ChP, JPC, USP

SMILES string

NC(CO)(CO)CO

InChI key

LENZDBCJOHFCAS-UHFFFAOYSA-N

InChI

1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

agency

BP
ChP
JPC
Ph. Eur.
USP

vapor pressure

0.0267 hPa ( 20 °C)

product line

EMPROVE® EXPERT

form

solid

pH

10.2-10.6 (20 °C, 6 g/L in H2O)

useful pH range

7-9

pKa (25 °C)

8.1

bp

219-220 °C/10 mmHg (lit.)
219-220 °C/13.3 hPa

mp

167-172 °C (lit.)

solubility

678 g/L

density

1.35 g/cm3 at 23 °C

application(s)

ophthalmics
pharmaceutical

storage temp.

no temp limit

Quality Level

500

Related Categories

Application

Tris(hydroxymethyl)aminomethane (Trometamol) is a commonly used buffer component in biomolecule downstream chromatography steps as well as final liquid formulation.

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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