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SAFC

Parteck® PLX 188 (Poloxamer 188)

(stabilized with 70ppm BHT), EMPROVE® ESSENTIAL, Ph. Eur., NF

Pharma Manufacturing

Synonym(s):

Poloxamer 188

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About This Item

Linear Formula:
(C3H6O · C2H4O)x
CAS Number:
9003-11-6
MDL number:
MFCD00082049
UNSPSC Code:
12352112

biological source

synthetic

Quality Level

500

Agency

NF
Ph. Eur.

product line

EMPROVE® ESSENTIAL

bp

>150 °C

mp

55 °C

bulk density

1050 kg/m3

storage temp.

2-25°C

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

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General description

With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid oral dosage forms. The products in our Parteck® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Parteck® PLX 188 excipient combines adequate lubrication at tolerable concentrations with the added benefit of dissolution enhancement. It features consistent performance, improved dissolution rate and reliable lubrication – all at the same time. As a result, Parteck® PLX 188 excipient can therefore provide a simple solution to low bioavailability of DCS 2a compounds.

Features and Benefits

  • Hydrophilic, water-soluble tablet lubrication
  • Improved dissolution rates for poorly soluble DCS class IIa molecules
  • Specified particle size distribution optimized for solid application performance
  • Regulatory support through compliance with Ph. Eur. and USP-NF, going beyond current requirements with specitied formaldehyde content

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Articles

API Solubility and Dissolution Enhancement Via Formulation

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