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Merck
CN

1.07428

Propyl 4-hydroxybenzoate sodium salt

EMPROVE® ESSENTIAL, Ph. Eur., BP, NF

Synonym(s):

Propyl 4-hydroxybenzoate sodium salt, 4-Hydroxybenzoic acid propyl ester sodium salt, Propylparaben sodium salt

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About This Item

Empirical Formula (Hill Notation):
C10H11NaO3
CAS Number:
35285-69-9
Molecular Weight:
202.18
UNSPSC Code:
12352108
EC Index Number:
252-488-1
MDL number:
MFCD00016477

Key Documents

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Product Name

Propyl 4-hydroxybenzoate sodium salt, EMPROVE® ESSENTIAL, Ph. Eur., BP, NF

SMILES string

[Na+].[O-]c1ccc(cc1)C(=O)OCCC

InChI

1S/C10H12O3.Na/c1-2-7-13-10(12)8-3-5-9(11)6-4-8;/h3-6,11H,2,7H2,1H3;/q;+1/p-1

InChI key

IXMINYBUNCWGER-UHFFFAOYSA-M

agency

BP
NF
Ph. Eur.

product line

EMPROVE® ESSENTIAL

form

solid

pH

9.5-10.5 (20 °C, 1 g/L in H2O)

mp

302 °C

density

1.24 g/cm3 at 25 °C

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

15-25°C

Quality Level

500

Related Categories

Application

Propyl 4-hydroxybenzoate has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics. It can be combined with other parabens like methyl 4-hydroxybenzoate or ethyl 4-hydroxybenzoate. The sodium salt provides improved solubility in water compared to standard propyl 4-hydroxybenzoate.

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

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Articles

Comparison of Preservatives Used in Various Therapeutic Applications

Find key considerations for the selection and use of benzalkonium chloride, benzyl alcohol, benzaldehyde, parabens, benzoic acid, and sodium benzoate as preservatives.

Criteria for Selecting Preservatives Used in Liquid Formulation

Find key considerations for the selection and use of preservatives in a range of different therapeutic applications including topical, oral, transmucosal, inhalation, and otic, as well as injectables.

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