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Merck
CN

1.07185

Pepsin

(from porcine gastric mucosa) 0.7 FIP-U/mg for biochemistry EC 3.4.23.1

Synonym(s):

Pepsin

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About This Item

CAS Number:
9001-75-6
Molecular Weight:
35000
UNSPSC Code:
12352204
EC Index Number:
232-629-3
NACRES:
NA.21
MDL number:
MFCD00081840

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Product Name

Pepsin, (from porcine gastric mucosa) 0.7 FIP-U/mg for biochemistry EC 3.4.23.1

pH

4.0-5.0 (20 °C, 10 g/L in H2O)

solubility

10 g/L

bulk density

380‑420 kg/m3

storage temp.

2-30°C

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Analysis Note

Appearance: fine, slightly yellow powder
Activity/FIP (Hemoglobin; pH 1.6; 25 °C): ≥ 0.70 FIP-U/mg
pH-value (1 %; water): 4.0 - 5.0
Water (according to Karl Fischer): ≤ 6.0 %

Application

Pepsin has been used in the preparation of simulated gastric fluid to perform in vitro gastric digestion.

Biochem/physiol Actions

Pepsin is a component of gastric juice and is associated with protein digestion. It is an endopeptidase that catalyzes the degradation of proteins into peptides and amino acids for small intestinal absorption. Pepsin is released as a zymogen (pepsinogen) by the chief cells of the gastric lining. It gets activated by the acidic environment created by the hydrochloric acid (HCl) of gastric juice. Pepsin is active at pH 1.5 to 2, in the stomach. It is involved in the conversion of food bolus into chyme. It is associated with laryngopharyngeal reflux (LPR) indicated by chronic cough, mild dysphagia, hoarseness, and non-productive throat clearing.

pictograms

Exclamation markHealth hazard
GHS07,GHS08

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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