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Supelco

8-Hydroxyquinoline

GR for analysis Reag. Ph Eur

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Synonym(s):
8-Hydroxyquinoline, Oxine, 8-Quinolinol
Empirical Formula (Hill Notation):
C9H7NO
CAS Number:
Molecular Weight:
145.16
MDL number:
UNSPSC Code:
12352104
EC Index Number:
205-711-1
NACRES:
NA.21

Agency

reag. Ph. Eur.

Quality Level

form

solid

potency

1200 mg/kg LD50, oral (Rat)

bp

267 °C/1013 hPa

mp

72.5-74.0 °C

density

1.034 g/cm3 at 20 °C

storage temp.

15-25°C

InChI

1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H

InChI key

MCJGNVYPOGVAJF-UHFFFAOYSA-N

Application


  • Pseudo-water-soluble Fe(2)O(3) as Nanozyme catalyzed chemiluminescent reaction for detection of brilliant blue in gelatin and beverages.: This innovative study utilizes 8-Hydroxyquinoline for enhancing chemiluminescent reactions in the detection of food colorants, presenting a new avenue in food safety and quality assurance techniques (Jabbar HS, 2024).

  • Enhanced selectivity towards melanoma cells with zinc(II)-Schiff bases containing imidazole derivatives.: Incorporating 8-Hydroxyquinoline in the development of zinc(II)-Schiff base complexes, this research demonstrates potential therapeutic applications in targeting melanoma cells, highlighting its role in medicinal chemistry (Côrte-Real et al., 2024).

  • Synthesis, crystal structure and anti-cancer activity of the complex chlorido-(η(2)-ethyl-ene)(quinolin-8-olato-κ(2)N,O)platinum(II) by experimental and theoretical methods.: This paper details the synthesis and anti-cancer properties of a novel platinum(II) complex using 8-Hydroxyquinoline, offering insights into its structural characteristics and therapeutic potential (Chi NTT et al., 2024).

  • Anticancer activity of 8-hydroxyquinoline-triphenylphosphine rhodium(III) complexes targeting mitophagy pathways.: Exploring the use of 8-Hydroxyquinoline in rhodium(III) complexes, this study provides a new perspective on targeting cancer cell metabolism, specifically through mitophagy pathways (Huang XQ et al., 2024).

  • Mitochondria-localizing triphenylphosphine-8-hydroxyquinoline Ru complexes induce ferroptosis and their antitumor evaluation.: This research examines the effectiveness of 8-Hydroxyquinoline complexes in inducing ferroptosis in cancer cells, a novel approach in cancer therapy focusing on oxidative cell death mechanisms (Meng T et al., 2024).

Analysis Note

Assay (perchloric acid titration): ≥ 99
Identity (IR-spectrum): passes test
Matter insoluble in ethanol: ≤ 0.05 %
Melting point: 73 - 75 °C
Chloride (Cl): ≤ 0.001 %
Sulfate (SO₄): ≤ 0.01 %
Sulfated ash: ≤ 0.05 %
Suitability as reagent (for Mg-test): passes test

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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