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1.04354

L-Histidine monohydrochloride monohydrate

Name: <SC>L</SC>-Histidine monohydrochloride monohydrate
Brand: MM

EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP

Pharma Manufacturing

Synonym(s):

His, L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₆H₉N₃O₂ · HCl · H₂O

CAS Number:

5934-29-2

Molecular Weight:

209.63

Beilstein:

4168261

MDL number:

MFCD00151027

UNSPSC Code:

12352107

EC Index Number:

211-438-9

Agency

BP
ChP
JP
Ph. Eur.

Quality Level

500

vapor pressure

<1 hPa ( 20 °C)

product line

EMPROVE^® EXPERT

Assay

98.5-101.0% (alkalimetric)
99.0-101.0% (perchloric acid titration)

form

solid

pH

3.5-4.5 (20 °C, 100 g/L in H₂O)

mp

254 °C (dec.) (lit.)

solubility

149.55 g/L

density

1.49 g/cm³ at 20 °C

application(s)

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

storage temp.

2-30°C

SMILES string

O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1

InChI key

CMXXUDSWGMGYLZ-XRIGFGBMSA-N

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Related Categories

Biopharmaceutical Formulation

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Injectables & Parenteral Formulations

Protein Stabilizers

General description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Histidine monohydrochloride is used in biopharmaceutical manufacturing as a buffer in formulation. It is often used along with histidine to prepare histidine buffer with the desired pH value.
Due to its low microbial and endotoxin limits, L-Histidine monohydrochloride monohydrate Emprove^® Expert is especially suitable for high-risk applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

also commonly purchased with this product

Product No.

Description

Pricing

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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