Skip to Content
Merck
CN
All Photos(3)

Documents

1.04352

SAFC

L-Histidine

EMPROVE® EXPERT, Ph. Eur., ChP, JP, USP

Pharma Manufacturing

Sign Into View Organizational & Contract Pricing
All Photos(3)
Synonym(s):
His, (S)-2-Amino-3-(4-imidazolyl)propionic acid, NSC 137773
Empirical Formula (Hill Notation):
C6H9N3O2
CAS Number:
71-00-1
Molecular Weight:
155.15
Beilstein:
84088
MDL number:
MFCD00064315
UNSPSC Code:
12352209
EC Index Number:
200-745-3

Agency

ChP
JP
Ph. Eur.
USP

Quality Level

500

product line

EMPROVE® EXPERT

form

solid

technique(s)

API processing | cocrystal formation: suitable

pH

7.7 (20 °C, 10 g/L in H2O)

mp

282 °C (dec.) (lit.)

application(s)

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

storage temp.

2-30°C

SMILES string

N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

InChI key

HNDVDQJCIGZPNO-YFKPBYRVSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Histidine is used in biopharma manufacturing as a buffer in formulation. It is often used together with histidine monohydrochloride to prepare histidine buffer with the desired pH value.
Due to its low microbial and endotoxin limits, L-Histidine Emprove® Expert is especially suitable for high-risk applications.

Biochem/physiol Actions

Precursor of histamine by action of histidine decarboxylase.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

Use of Stabilizers and Surfactants to Prevent Protein Aggregation

This article outlines critical factors in long-term stability of proteins, and how different stabilizers protect again mechanical and thermal stress.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service