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1.02584

Caffeine

EMPROVE® ESSENTIAL Ph Eur,BP,USP

Synonym(s):

Caffeine, 7-Methyltheobromine, 1,3,7-Trimethylxanthine, 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione

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About This Item

Empirical Formula (Hill Notation):
C8H10N4O2
CAS Number:
58-08-2
Molecular Weight:
194.19
UNSPSC Code:
12352115
EC Index Number:
200-362-1
MDL number:
MFCD00005758
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Quality Level

500

agency

BP, Ph. Eur., USP

vapor pressure

20 hPa ( 80 °C)

product line

EMPROVE® ESSENTIAL

assay

98.5-101.0% (HPLC), 98.5-101.0% (perchloric acid titration)

form

crystalline powder

autoignition temp.

>600 °C

potency

367.7 mg/kg LD50, oral (Rat)

technique(s)

API processing | cocrystal formation: suitable

pH

5.5-6.5 (20 °C, 10 g/L in H2O)

mp

235-239 °C

solubility

20 g/L

density

1.23 g/cm3 at 18 °C

application(s)

pharmaceutical

storage temp.

2-30°C

SMILES string

[n]1(c2c(nc1)N(C(=O)N(C2=O)C)C)C

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

General description

We offer a range of high quality critical raw materials, solvents and reagents plus the documentation and expertise to meet stringent regulatory requirements. In addition to our comprehensive portfolio, we also offer custom manufacturing services to meet your exact needs. As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Caffeine Emprove® Essential is suitable for pharmaceutical applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

Regulatory Information

监管及禁止进口产品

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Protocols

Protocol for In-vitro Permeation Testing Using Strat-M® Membranes

Strat-M® synthetic membrane mimics the human skin for In-vitro permeation testing (IVPT) of topical and transdermal formulations

Articles

Improving API Solubility using API Processing

Instead of addressing API solubility during formulation, tackle it early during development. Read about the various methods for API processing.

Global Trade Item Number

SKUGTIN
102584100004022536034980
102584905004022536035000