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SAFC

Ethyl 4-hydroxybenzoate sodium salt

EMPROVE® ESSENTIAL, Ph. Eur., BP, NF

Pharma Manufacturing

Synonym(s):

Ethyl 4-hydroxybenzoate sodium salt, p-Hydroxybenzoic acid ethyl ester sodium salt, Ethylparaben sodium salt

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About This Item

Empirical Formula (Hill Notation):
C9H9NaO3
CAS Number:
35285-68-8
Molecular Weight:
188.16
UNSPSC Code:
12352108
EC Index Number:
252-487-6

Agency

BP
NF
Ph. Eur.

Quality Level

500

product line

EMPROVE® ESSENTIAL

form

solid

pH

10 (20 °C, 1 g/L in H2O)

bp

297 °C/1013 hPa (free ester,decomposition)

mp

>115 °C (free ester)

transition temp

flash point 121 °C

solubility

1000 g/L

application(s)

liquid formulation
ophthalmics
pharmaceutical

storage temp.

15-25°C

InChI

1S/C9H10O3.Na/c1-2-12-9(11)7-3-5-8(10)6-4-7;/h3-6,10H,2H2,1H3;/q;+1/p-1

InChI key

QYNMSPKSYXPZHG-UHFFFAOYSA-M

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General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Ethyl 4-hydroxybenzoate has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics. It can be combined with other parabens like methyl 4-hydroxybenzoate or propyl 4-hydroxybenzoate. The sodium salt provides improved solubility in water compared to standard ethyl 4-hydroxybenzoate.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H318

Precautionary Statements

P280 - P305 + P351 + P338

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

249.8 °F

Flash Point(C)

121 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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