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SAFC

Salicylic acid

fine powder EMPROVE® ESSENTIAL Ph Eur,BP,USP

Pharma Manufacturing

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Synonym(s):
Salicylic acid, 2-Hydroxybenzoic acid
Empirical Formula (Hill Notation):
C7H6O3
CAS Number:
69-72-7
Molecular Weight:
138.12
MDL number:
MFCD00002439
UNSPSC Code:
12352106
EC Index Number:
200-712-3

Agency

BP
Ph. Eur.
USP

Quality Level

500

vapor pressure

<1 hPa ( 100 °C)

product line

EMPROVE® ESSENTIAL

Assay

98.0-102.0% dry basis (HPLC)

form

solid

autoignition temp.

500 °C

potency

1250-1580 mg/kg LD50, oral (Rat)
>2000 mg/kg LD50, skin (Rat)

technique(s)

tissue culture: suitable

pH

2.4 ( in H2O, saturated solution)

bp

211 °C/1013 hPa

mp

157-159 °C

transition temp

flash point 157 °C

solubility

water: 2 g/L at 20 °C

density

1.443 g/cm3 at 20 °C

bulk density

400‑500 kg/m3

anion traces

chloride (Cl-): ≤0.0100%
sulfate (SO42-): ≤0.0200%

application(s)

liquid formulation
pharmaceutical

storage temp.

15-25°C

InChI

1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)

InChI key

YGSDEFSMJLZEOE-UHFFFAOYSA-N

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General description

We offer a range of high quality critical raw materials, solvents and reagents plus the documentation and expertise to meet stringent regulatory requirements. In addition to our comprehensive portfolio, we also offer custom manufacturing services to meet your exact needs. As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Salicylic acid is used in dermatological medicine for skin exfoliating and acne. Salicylic acid Emprove® Essential is suitable for pharmaceutical applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Signal Word

Danger

Hazard Statements

H302,H318,H361d

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 2

WGK

WGK 1

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Protocols

Determination of Water Content in Amino acids Using Karl Fischer Titration

With the exception of prolin, amino acids are hardly soluble in alcohols. Therefore, only the adherent moisture can be determined by the direct volumetric method.

Determination of Water Content in Triethylamine Using Karl Fischer Titration

Summary application report for analysis of moisture in Triethylamine

Determination of Water Content in 2-Aminoethanol, Ethanolamine Using Karl Fischer Titration

Summary application report for analysis of moisture in 2-Aminoethanol, Ethanolamin

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