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Safety Information

1.00563

SAFC

ortho-Phosphoric acid

85%, EMPROVE® ESSENTIAL, Ph. Eur., BP, JPE, NF, E 338

Pharma Manufacturing

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Synonym(s):
Phosphoric acid, o-Phosphoric acid, Orthophosphoric acid, Orthophosphoric acid
Linear Formula:
H3PO4
CAS Number:
7664-38-2
Molecular Weight:
98.00
Beilstein:
1921286
MDL number:
MFCD00011340
UNSPSC Code:
12352301
E Number:
E338

Agency

BP
JPE
NF
Ph. Eur.

Quality Level

500

vapor density

3.4 (vs air)

vapor pressure

2.2 mmHg ( 20 °C)
5 mmHg ( 25 °C)

product line

EMPROVE® ESSENTIAL

form

liquid

concentration

85%

technique(s)

API processing | salt formation: suitable

pH

<0.5 (20 °C, 100 g/L in H2O)

kinematic viscosity

30.5 cSt(20 °C)

bp

158 °C (lit.)

mp

~40 °C (lit.)

density

1.685 g/mL at 25 °C (lit.)

application(s)

liquid formulation
ophthalmics
pharma/biopharma processes
pharmaceutical
semi-solid formulation

storage temp.

2-30°C

SMILES string

OP(O)(O)=O

InChI

1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)

InChI key

NBIIXXVUZAFLBC-UHFFFAOYSA-N

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General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Phosphoric acid can be used as acidifying agent in a variety of pharmaceutical formulations and processes.

Other Notes

Concentrated phosphoric acid is approx. 85% H3PO4 (aqueous).

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H290,H302,H314

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

WGK

WGK 1

Flash Point(F)

does not flash

Flash Point(C)

does not flash

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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