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Safety Information

1.00263

SAFC

Formic acid

98-100%, EMPROVE® ESSENTIAL

Pharma Manufacturing

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Synonym(s):
Formic acid, Methanoic acid, Formylic acid
Linear Formula:
HCOOH
CAS Number:
64-18-6
Molecular Weight:
46.03
Beilstein:
1209246
MDL number:
MFCD00003297
UNSPSC Code:
12352106
EC Index Number:
200-579-1

vapor density

1.6 (vs air)

Quality Level

500

vapor pressure

44.8 mmHg ( 20 °C)

product line

EMPROVE® ESSENTIAL

Assay

≥98% (alkalimetric)

form

liquid

autoignition temp.

1004 °F

expl. lim.

12-38 % (v/v)
57 %

concentration

98-100%

technique(s)

API processing | polymorph screening: suitable
API processing | salt formation: suitable

refractive index

n20/D 1.370 (lit.)

pH

2.2 (20 °C, 10 g/L in H2O)

bp

100-101 °C (lit.)
101 °C/1013 hPa

mp

8.2-8.4 °C (lit.)

transition temp

flash point 49.5 °C

density

1.22 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤0.001%
sulfate (SO42-): ≤0.004%
sulfite (SO32-): ≤0.002%

cation traces

As: ≤0.0003%
Cu: ≤0.002%
Pb: ≤0.001%
Zn: ≤0.002%
heavy metals (as Pb): ≤0.0005%

application(s)

liquid formulation
pharmaceutical

storage temp.

15-25°C

SMILES string

OC=O

InChI

1S/CH2O2/c2-1-3/h1H,(H,2,3)

InChI key

BDAGIHXWWSANSR-UHFFFAOYSA-N

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General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Formic acid can be used as acidifying agent and buffer component in a variety of pharmaceutical formulations and processes.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Statements

H226,H302,H314,H331

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A

Supplementary Hazards

EUH071

WGK

WGK 1

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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