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Safety Information

1.00160

SAFC

Boric acid

crystalline, EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, NF

Pharma Manufacturing

Synonym(s):

Orthoboric acid, Trihydroxidoboron

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About This Item

Linear Formula:
H3BO3
CAS Number:
10043-35-3
Molecular Weight:
61.83
MDL number:
MFCD00011337
UNSPSC Code:
12352301
EC Index Number:
233-139-2

Agency

BP
JP
NF
Ph. Eur.

Quality Level

500

vapor pressure

2.6 mmHg ( 20 °C)

product line

EMPROVE® ESSENTIAL

Assay

99.5-100.5% dry basis (alkalimetric)

form

crystalline
solid

technique(s)

API processing | cocrystal formation: suitable
API processing | salt formation: suitable

pH

3.8-4.8 (20 °C, 33 g/L in H2O)

mp

160 °C (dec.) (lit.)

solubility

49.2 g/L

density

1.489 g/cm3 at 23 °C

anion traces

sulfate (SO42-): ≤0.04%

cation traces

As: ≤0.0001%
heavy metals (as Pb): ≤0.0015%

application(s)

liquid formulation
ophthalmics
pharmaceutical
semi-solid formulation

storage temp.

2-30°C

SMILES string

OB(O)O

InChI

1S/BH3O3/c2-1(3)4/h2-4H

InChI key

KGBXLFKZBHKPEV-UHFFFAOYSA-N

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General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Boric acid has antimicrobial characteristics and is therefore typically used as preservative in pharmaceutical formulations and cosmetics. It is also used as buffering agent and pH adjuster.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360FD

Hazard Classifications

Repr. 1B

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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