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100069

Sigma-Aldrich

17-DMAG

A potent antitumor analog of 17-AAG that binds to the ATPase site of human Hsp90α with high affinity and displays excellent bioavailability and aqueous solubility.

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Synonym(s):
17-DMAG, NSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG
Empirical Formula (Hill Notation):
C32H48N4O8 · xHCl
CAS Number:
467214-21-7
Molecular Weight:
616.75 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥95% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

purple

solubility

water: 10 mg/mL
DMSO: 5 mg/mL

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C32H48N4O8.ClH/c1-18-14-22-27(34-12-13-36(5)6)24(37)17-23(29(22)39)35-31(40)19(2)10-9-11-25(42-7)30(44-32(33)41)21(4)16-20(3)28(38)26(15-18)43-8;/h9-11,16-18,20,25-26,28,30,34,38H,12-15H2,1-8H3,(H2,33,41)(H,35,40);1H/b11-9-,19-10+,21-16+;/t18-,20+,25+,26+,28-,30+;/m1./s1

InChI key

DFSYBWLNYPEFJK-IHLRWNDRSA-N

General description

A cell-permeable, water soluble, potent anti-tumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen).
A potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen), and displays excellent bioavailability and aqueous solubility.

Biochem/physiol Actions

Cell permeable: no
GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen
Primary Target
17-DMAG
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Tian, Z.Q., et al. 2004. Bioorg. Med. Chem.12, 5317.
Jez, J.M., et al. 2003. Chem. Biol.10, 361.
Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol.49, 7.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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