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SAFC

Tri-n-butyl phosphate

EMPROVE® EXPERT, Ph. Eur.

Pharma Manufacturing

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Synonym(s):
Tributyl phosphate, TBP, TBPA
Linear Formula:
(CH3(CH2)3O)3PO
CAS Number:
126-73-8
Molecular Weight:
266.31
Beilstein:
1710584
MDL number:
MFCD00009436
UNSPSC Code:
12352303
EC Index Number:
204-800-2

Agency

Ph. Eur.

Quality Level

500

vapor density

9.2 (vs air)

vapor pressure

27 mmHg ( 178 °C)
7.3 mmHg ( 150 °C)

product line

EMPROVE® EXPERT

form

liquid

autoignition temp.

770 °F

refractive index

n20/D 1.424 (lit.)

bp

180-183 °C/22 mmHg (lit.)

mp

−79 °C (lit.)

transition temp

flash point 146 °C

solubility

6 g/L

density

0.979 g/mL at 25 °C (lit.)

application(s)

liquid formulation
pharma/biopharma processes
pharmaceutical

storage temp.

15-25°C

SMILES string

CCCCOP(=O)(OCCCC)OCCCC

InChI

1S/C12H27O4P/c1-4-7-10-14-17(13,15-11-8-5-2)16-12-9-6-3/h4-12H2,1-3H3

InChI key

STCOOQWBFONSKY-UHFFFAOYSA-N

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General description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Tri-n-butyl phosphate is used widely as a solvent along with either TritonTM X100 or Tween® in solvent detergent treatment for viral inactivation procedures especially for plasma derived therapeutics.
Due to its low microbial and endotoxin limits, Tri-n-butyl phosphate Emprove® Expert is especially suitable for high-risk applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
TWEEN is a registered trademark of Croda International PLC

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H351,H412

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Skin Irrit. 2

WGK

WGK 2

Flash Point(F)

293.0 °F

Flash Point(C)

145 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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