09-814
Anti-dimethyl-Arginine Antibody, asymmetric (ASYM25)
serum, from rabbit
Synonym(s):
dimethyl-arginine, asymmetric
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse
species reactivity (predicted by homology)
rat (based on 100% sequence homology), human (based on 100% sequence homology)
technique(s)
western blot: suitable
shipped in
wet ice
target post-translational modification
unmodified
General description
Asymmetrical dimethlarginine (ADMA) is an endogenous, L-arginine metabolite arising from the proteolysis of methylated arginine containing proteins and is a known inhibitor of nitric oxide synthase (NOS). In various studies, ADMA has been observed as having a regulatory role in cell motility and the actin cytoskeleton. Elevated levels of ADMA are associated with sporadic FSGS, coronary artery disease, hypertension, peripheral arterial occlusive disease, obesity, stroke, preeclampsia, and cardiovascular mortality/morbidity in patients with diabetic nephropathy.
Specificity
This antibody recognizes dimethylated arginines.
Immunogen
KLH-conjugated linear peptide containing asymmetric dimethyl-arginine-glycine repeats.
Application
Detect dimethyl-Arginine using this Anti-dimethyl-Arginine Antibody, asymmetric (ASYM25) validated for use in WB.
Quality
Evaluated by Western Blot in PRMT1 treated and untreated MEF cell lysates.
Western Blot Analysis: 1:1,000 dilution of this antibody detected dimethyl-Arginine on 10 µg of PRMT1 treated and untreated MEF cell lysates.
Western Blot Analysis: 1:1,000 dilution of this antibody detected dimethyl-Arginine on 10 µg of PRMT1 treated and untreated MEF cell lysates.
Target description
Multiple. This antibody detects proteins containing asymmetrical dimethylated arginines.
Analysis Note
Control
PRMT1 treated and untreated MEF cell lysates
PRMT1 treated and untreated MEF cell lysates
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WGK 1
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