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biological source
rabbit
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human, rat
manufacturer/tradename
Upstate®
technique(s)
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
mouse ... Lingo1(235402)
Specificity
LINGO-1
Immunogen
KLH-conjugated, synthetic peptide corresponding to amino acid residues 611-620 of human LINGO-1 (APRKFNMKMI)
Application
Detect LINGO-1 using this Anti-LINGO-1 Antibody validated for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Quality
routinely evaluated by immunoblot on mouse brain membrane samples.
Target description
Mr ~83kDa
Physical form
Format: Purified
Protein A purified
Storage and Stability
stable for 2 years at -20°C from date of shipment
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 2
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Alexandra Trifunovski et al.
Neuroreport, 15(15), 2397-2400 (2005-01-11)
Axonal regeneration after injury can be limited in the adult CNS by the presence of inhibitory proteins such as Nogo. Nogo binds to a receptor complex that consists of Nogo receptor (NgR), p75NTR, and Lingo-1. Nogo binding activates RhoA, which
Multi-tasking by the p75 neurotrophin receptor: sortilin things out?
Bronfman, Francisca C and Fainzilber, Mike
EMBO Reports, 5, 867-871 (2004)
TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions.
J Satoh, H Tabunoki, T Yamamura, K Arima, H Konno
Neuropathology and Applied Neurobiology null
Lingo-1 expression is increased in essential tremor cerebellum and is present in the basket cell pinceau.
Kuo, SH; Tang, G; Louis, ED; Ma, K; Babji, R; Balatbat, M; Cortes, E; Vonsattel et al.
Acta neuropathologica null
Sha Mi et al.
Nature neuroscience, 7(3), 221-228 (2004-02-18)
Axon regeneration in the adult CNS is prevented by inhibitors in myelin. These inhibitors seem to modulate RhoA activity by binding to a receptor complex comprising a ligand-binding subunit (the Nogo-66 receptor NgR1) and a signal transducing subunit (the neurotrophin
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