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Merck
CN

07-631

Anti-cdk2 Antibody

Upstate®, from rabbit

Synonym(s):

Anti-CDKN2, Anti-p33(CDK2)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Key Documents

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Product Name

Anti-cdk2 Antibody, Upstate®, from rabbit

biological source

rabbit

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_001798

UniProt accession no.

P24941

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CDK2AP1(8099)

Analysis Note

Control
Colon tissue
routinely evaluated by immunoblot in nuclear extracts from HeLa cells

Application

Anti-cdk2 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of cdk2 & has been validated in IP & WB.

Biochem/physiol Actions

Predicted to cross-react with mouse, rat, non-human primates, and hamster based on sequence homology
Recognizes human p33cdk2 protein kinase.

General description

33 kDa

Immunogen

peptide corresponding to amino acids 287-298 (C-QDVTKPVPHLRL) of human cdk2

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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C S Rani et al.
The Journal of biological chemistry, 272(16), 10777-10783 (1997-04-18)
Platelet-derived growth factor (PDGF) and serum, but not epidermal growth factor (EGF), stimulated sphingosine kinase activity in Swiss 3T3 fibroblasts and increased intracellular concentrations of sphingosine 1-phosphate (SPP), a sphingolipid second messenger (Olivera, A., and Spiegel, S. (1993) Nature 365
CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.
Elledge, S J, et al.
Proceedings of the National Academy of Sciences of the USA, 89, 2907-2911 (1992)
Carlotta Costa et al.
Cancer discovery, 10(1), 72-85 (2019-10-09)
The combination of CDK4/6 inhibitors with antiestrogen therapies significantly improves clinical outcomes in ER-positive advanced breast cancer. To identify mechanisms of acquired resistance, we analyzed serial biopsies and rapid autopsies from patients treated with the combination of the CDK4/6 inhibitor
Sublytic complement attack induces cell cycle in oligodendrocytes.
Rus, H G, et al.
Journal of immunology (Baltimore, Md. : 1950), 156, 4892-4900 (1996)
Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants.
Restle, A; Farber, M; Baumann, C; Bohringer, M; Scheidtmann, KH; Muller-Tidow, C; Wiesmuller, L
Nucleic Acids Research null
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