07-227
Anti-p34-Arc/ARPC2 Antibody
Upstate®, from rabbit
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
Quality Level
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
Gene Information
human ... ARPC2(10109)
Specificity
Recognizes p34-Arc/ARPC2 of the Arp2/3 complex.
Immunogen
Peptide corresponding to amino acids 285-298 of human Arc
Application
Anti-p34-Arc/ARPC2 Antibody detects level of p34-Arc/ARPC2 & has been published & validated for use in IC, IH & WB.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Cytoskeleton
Cytoskeleton
Quality
routinely evaluated by immunoblot on RIPA lysates from human A431, Jurkat, and mouse 3T3 cells
Target description
34 kDa
Physical form
Format: Purified
Protein A Purified immunoglobulin in 0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol.
Protein A purified
Storage and Stability
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Analysis Note
Control
Positive Control Included: Non-Stim A431 Cell Lysate (12-301)
Positive Control Included: Non-Stim A431 Cell Lysate (12-301)
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Formation of adherens junctions leads to the emergence of a tissue-level tension in epithelial monolayers.
Harris, AR; Daeden, A; Charras, GT
Journal of Cell Science null
Structural basis for regulation of Arp2/3 complex by GMF.
Luan, Q; Nolen, BJ
Nature Structural and Molecular Biology null
The role of Arp2/3 in growth cone actin dynamics and guidance is substrate dependent.
San Miguel-Ruiz, JE; Letourneau, PC
The Journal of Neuroscience null
Organization of the Arp2/3 complex in hippocampal spines.
Racz, B; Weinberg, RJ
The Journal of Neuroscience null
Vera Dugina et al.
Oncotarget, 6(16), 14556-14571 (2015-05-27)
Here we have shown that β-cytoplasmic actin acts as a tumor suppressor, inhibiting cell growth and invasion in vitro and tumor growth in vivo. In contrast, γ-cytoplasmic actin increases the oncogenic potential via ERK1/2, p34-Arc, WAVE2, cofilin1, PP1 and other
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