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Merck
CN

07-204

Anti-Sec61α Antibody

serum, Upstate®

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
monoclonal, polyclonal
Application:
IP, WB
Citations:
19

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

serum

antibody product type

primary antibodies

clone

monoclonal, polyclonal

species reactivity

canine, rat, human

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG

NCBI accession no.

NM_013336, NM_018144

UniProt accession no.

P61619

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SEC61A1(29927)

General description

40kDa

Immunogen

peptide conjugated to KLH and to BSA, corresponding to amino acids 463-476 of human Sec61a (C-KEQSEVGSMGALLF)

Application

Detect Sec61α using this Anti-Sec61α Antibody validated for use in IP & WB.
Research Category
Metabolism
Research Sub Category
Ion & Transport Channels

Biochem/physiol Actions

Sec61α

Physical form

Antiserum
antiserum containing 0.05% sodium azide and 30% glycerol

Preparation Note

2 years at -20°C

Analysis Note

routinely evaluated by immunoblot on a rat brain microsomal preparation

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A posttargeting signal sequence recognition event in the endoplasmic reticulum membrane.
Jungnickel, B and Rapoport, T A
Cell, 82, 261-270 (1995)
D Görlich et al.
Cell, 71(3), 489-503 (1992-10-30)
SEC61p is essential for protein translocation across the endoplasmic reticulum membrane of S. cerevisiae. We have found a mammalian homolog that shows more than 50% sequence identity with the yeast protein. Moreover, several regions of SEC61p have significant similarities with
Mutation of juxtamembrane cysteines in the tetraspanin CD81 affects palmitoylation and alters interaction with other proteins at the cell surface.
Caroline Delandre,Taryn R Penabaz,A Lorena Passarelli,Stephen K Chapes,Rollie J Clem
Experimental Cell Research null
W Mothes et al.
The EMBO journal, 13(17), 3973-3982 (1994-09-01)
We have extended a previously developed photo-crosslinking approach to systematically probe the protein environment of the secretory protein preprolactin, trapped during its transfer through the endoplasmic reticulum membrane. Single photoreactive groups were placed at various positions of nascent polypeptide chains
Hydrophobic and basic domains target proteins to lipid droplets.
Ingelmo-Torres, M; Gonzalez-Moreno, E; Kassan, A; Hanzal-Bayer, M; Tebar, F; Herms et al.
Traffic null
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