06-237
Anti-Gsα Antibody
serum, Upstate®
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Product Name
Anti-Gsα Antibody, serum, Upstate®
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, human, bovine
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GNAS(2778)
Analysis Note
Control
Widely expressed
Widely expressed
routinely evaluated by immunoblot on rat brain microsomal preparation (Catalog #12-144)
Application
Anti-Gsα Antibody is an antibody against Gsα for use in IC, IP & WB.
Research Category
Signaling
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling
GPCR, cAMP/cGMP & Calcium Signaling
Biochem/physiol Actions
Recognizes the large and small forms of Gsα; does not cross-react with other G proteins.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
large isoform (52 kDa) and small isoform (45 kDa)
Immunogen
peptide corresponding to the c-terminus of bovine Gsα (RMHLRQYELL); this sequence is present in all three isoforms of human Gsα (Gsα1, Gsα2, and GsαXL)
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Replaces: AB1639
Physical form
Protein A purified
Serum diluted 1:1 in PBS.
Preparation Note
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class
10 - Combustible liquids
wgk
WGK 2
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Harinder Singh et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 43(7), 1481-1491 (2018-02-22)
Current antidepressant therapies meet with variable therapeutic success and there is increasing interest in therapeutic approaches not based on monoamine signaling. Histone deacetylase 6 (HDAC6), which also deacetylates α-tubulin shows altered expression in mood disorders and HDAC6 knockout mice mimic
Parathyroid hormone signaling via G?s is selectively inhibited by an NH(2)-terminally truncated G?s: implications for pseudohypoparathyroidism.
Svetlana Puzhko,Cynthia Gates Goodyer,Mohammad Amin Kerachian,Lucie Canaff et al.
Journal of Bone and Mineral Research null
Elie Seaayfan et al.
Cells, 11(21) (2022-11-12)
Hypoxia stabilizes the transcription factor HIF-1α, which promotes the transcription of many genes essential to adapt to reduced oxygen levels. Besides proline hydroxylation, expression of HIF-1α is also regulated by a range of other posttranslational modifications including phosphorylation by cAMP-dependent
Yan Zhu et al.
Endocrinology, 157(2), 497-507 (2015-12-17)
PTH regulates serum calcium, phosphate, and 1,25-dihydroxyvitamin D (1,25(OH)2D) levels by acting on bone and kidney. In renal proximal tubules (PTs), PTH inhibits reabsorption of phosphate and stimulates the synthesis of 1,25(OH)2D. The PTH receptor couples to multiple G proteins.
Bo Li et al.
FEBS letters, 587(5), 410-416 (2013-01-29)
β-Arrestins function to mediate G protein-coupled receptor (GPCR) desensitization and internalization and to initiate G protein independent signaling of GPCRs. Elucidating how β-arrestin and G protein signal pathways coordinate with each other is important to fully understand GPCR signaling. Here
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