06-1119
Anti-TLR2 Antibody
from rabbit, purified by affinity chromatography
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Synonym(s):
toll-like receptor 2, Toll/interleukin-1 receptor-like protein 4, toll/interleukin 1 receptor-like 4, CD282 antigen
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human, mouse
species reactivity (predicted by homology)
chimpanzee (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... TLR2(7097)
mouse ... Tlr2(24088)
General description
Toll-like receptor 2 (TLR2) is a single-pass type I membrane protein belonging to the Toll-like receptor family and is comprised of 14 LRR repeats and a single TIR domain. TLR2 interacts with LY96 or TLR1 to regulate innate immune response to bacterial lipoproteins and other components of the microbial cell wall. It induces the activation of NFκB, inflammatory response and cytokine secretion through interactions with MYD88 and TRAF6. It may also function as a promoter for apoptosis. High expression of TLR2 has been reported in blood leukocytes, specifically in bone marrow, lymph node, monocytes and spleen. It has also been observed in fetal liver and lung tissues. Modifications in gene expression have been implicated in an increased susceptibility to leprosy.
Specificity
This antibody recognizes the extracellular domain of TLR2.
Immunogen
Epitope: Extracellular Domain
KLH-conjugated linear peptide corresponding to the extracellular domain of human TLR2.
Application
Anti-TLR2 Antibody is an antibody against TLR2 for use in WB, IH(P).
Immunohistochemistry Analysis: A 1:50 dilution from a previous lot detected TLR2 in normal human placenta tissue.
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology
Immunoglobulins & Immunology
Quality
Evaluated by Western Blot in RAW264.7 cell lysate.
Western Blot Analysis: 2 µg/mL of this antibody detected TLR2 in 10 µg of RAW264.7 cell lysate.
Western Blot Analysis: 2 µg/mL of this antibody detected TLR2 in 10 µg of RAW264.7 cell lysate.
Target description
~90 kDa observed.
Blocking without Tween is recommended to avoid the observance of additional bands.
Blocking without Tween is recommended to avoid the observance of additional bands.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
RAW264.7 cell lysate
RAW264.7 cell lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Rajalakshmi Ramamoorthy et al.
Biology, 12(8) (2023-08-26)
Signs and symptoms involving multiple organ systems which persist for weeks or months to years after the initial SARS-CoV-2 infection (also known as PASC or long COVID) are common complications of individuals with COVID-19. We recently reported pathophysiological changes in
Marcela Alcântara Proença et al.
World journal of gastroenterology, 21(25), 7730-7741 (2015-07-15)
To evaluate the effect of promoter region polymorphisms of toll-like receptor (TLR)2-196 to -174del and TLR4-1607T/C (rs10759932) on mRNA and protein expression in tumor tissue and of TLR4+896A/G (rs4986790) on colorectal cancer (CRC) risk. The TLR2-196 to -174del polymorphism was
Effect of Helicobacter pylori eradication on TLR2 and TLR4 expression in patients with gastric lesions.
Cadamuro, AC; Rossi, AF; Matos Biselli-Perico, J; Fucuta Pereira, P; Do Vale, EP; Acayaba et al.
Mediators of Inflammation null
Laminin forms an independent network in basement membranes.
P D Yurchenco,Y S Cheng,H Colognato
The Journal of cell biology null
Tania Wong Fok Lung et al.
Nature microbiology, 5(1), 141-153 (2019-11-07)
Staphylococcus aureus small colony variants (SCVs) are frequently associated with chronic infection, yet they lack expression of many virulence determinants associated with the pathogenicity of wild-type strains. We found that both wild-type S. aureus and a ΔhemB SCV prototype potently
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