06-1116
Anti-IL-33R ST2 (IL1RL1) Antibody
from rabbit, purified by affinity chromatography
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Synonym(s):
interleukin 1 receptor-like 1, interleukin-1 receptor-like 1, growth stimulation-expressed, homolog of mouse growth stimulation-expressed, interleukin 1 receptor-related protein, Protein ST23
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
antibody form
affinity isolated antibody
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
species reactivity (predicted by homology)
primate (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
General description
Interleukin-1 receptor-like 1 (IL-33R ST2) is a member of the interleukin-1 receptor family, and is comprised of three Ig-like C2-type domains and a single TIR domain. IL-33R ST2 functions as a receptor for IL-33, and, following phosphorylation with MAPKa/ERK2, MAPK3/ERK1, MAPK8 and/ore MAPK14, serves to recruit IRAK1, IRAk4, MYD88, and TRAF6. It is also thought to have a potential role in the function of helper T-cells. High expression has been reported in colon, kidney, lung, placenta, skeletal muscle, small intestines, and the stomach. Isoform A has been noted to be more prevalent in colon, lung, placenta, testis and stomach, while Isoform B has greater presence in brain, liver and kidney.
Specificity
This antibody recognizes the extracellular domain of IL-33R ST2.
Immunogen
Epitope: Extracellular Domain
KLH-conjugated linear peptide corresponding to the extracellular domain of human IL-33R ST2.
Application
Anti-IL-33R ST2 (IL1RL1) Antibody is an antibody against IL-33R ST2 (IL1RL1) for use in WB, IH(P).
Immunohistochemistry Analysis: A 1:300 dilution from a previous lot detected IL-33R ST2 in normal human thymus tissue.
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Cytokines & Cytokine Receptors
Cytokines & Cytokine Receptors
Quality
Evaluated by Western Blot in human kidney tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-33R ST2 in 10 µg of human kidney tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-33R ST2 in 10 µg of human kidney tissue lysate.
Target description
~30 kDa observed.
UniProtKB/Swiss-Prot Q01638 (ILRL1_HUMAN) entry describes 3 isoforms produced by alternative splicing: Isoform A at 63.358 kDa, Isoform B at 36.993 kDa, Isoform C at 29.951 kDa The ~37 kDa product is the secreted form.
UniProtKB/Swiss-Prot Q01638 (ILRL1_HUMAN) entry describes 3 isoforms produced by alternative splicing: Isoform A at 63.358 kDa, Isoform B at 36.993 kDa, Isoform C at 29.951 kDa The ~37 kDa product is the secreted form.
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Human kidney tissue lysate
Human kidney tissue lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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