06-1115
Anti-Interleukin-18 (IL-18) Antibody
from rabbit, purified by affinity chromatography
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Synonym(s):
interleukin 18 (interferon-gamma-inducing factor), IL-1 gamma, IFN-gamma-inducing factor, iboctadekin, interleukin-18, Interleukin-1 gamma, Iboctadekin, Interferon gamma-inducing factor
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
species reactivity (predicted by homology)
rhesus macaque (based on 100% sequence homology), chimpanzee (based on 100% sequence homology), primate (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... IL18(3606)
General description
IL-18 has been shown to be a pro-inflammatory cytokine that induces interferon-gamma. IL-18 has also been found to have the ability to activate nuclear factor-kappaB (NFkB), express Fas ligand, induce CC and CXC chemokines, and also has been found to increase the production of viable human immunodeficiency virus. IL-18 has been linked to syndromes displaying symptoms of chronic low-levels of inflammation. IL-18 also seems to have some control over homeostasis and behavior in the central nervous system as well as neuroinflammatory activity.
Immunogen
KLH-conjugated linear peptide corresponding to human Interleukin-18.
Application
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Cytokines & Cytokine Receptors
Cytokines & Cytokine Receptors
This Anti-Interleukin-18 (IL-18) Antibody is validated for use in WB, IH(P) for the detection of Interleukin-18 (IL-18).
Western Blot (Snap i.d.) Analysis: 5 µg/mL from a previous lot detected IL-18 in 10 µg of human tonsil tissue lysate.
Immunohistochemistry Analysis: A 1:600 dilution from a previous lot detected IL-18 in normal human spleen tissue.
Immunohistochemistry Analysis: A 1:600 dilution from a previous lot detected IL-18 in normal human spleen tissue.
Quality
Evaluated by Western Blot in human tonsil tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-18 in 10 µg of human tonsil tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-18 in 10 µg of human tonsil tissue lysate.
Target description
~22 kDa observed
Physical form
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage and Stability
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
Human tonsil tissue lysate
Human tonsil tissue lysate
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Chang-Lun Huang et al.
Molecular medicine reports, 28(4) (2023-09-01)
Human parvovirus B19 (B19V) has been strongly associated with a variety of inflammatory disorders, such as rheumatoid arthritis (RA), inflammatory bowel disease and systemic lupus erythematosus. Non‑structural protein 1 (NS1) of B19V has been demonstrated to play essential roles in
C Baldini et al.
Journal of internal medicine, 274(5), 480-489 (2013-08-03)
Innate and adaptive immunity may contribute to gland dysfunction in patients with primary Sjögren's syndrome (pSS). The P2X7 receptor (P2X7 R)-NLRP3 inflammasome complex modulates the release of the inflammatory cytokines IL-1β and IL-18. The presence of P2X7 R in salivary
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