05-883
Anti-tPA (Tissue Plasminogen Activator) Antibody, clone GMA-043
clone GMA-043, Upstate®, from mouse
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Synonym(s):
Anti-BAT-PA, Anti-DSPA-5
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
GMA-043, monoclonal
species reactivity
human
manufacturer/tradename
Upstate®
technique(s)
ELISA: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... PLAT(5327)
mouse ... Plat(18791)
Specificity
tPA
Immunogen
Purified human tissue plasminogen activator (tPA)
Application
Detect tPA (Tissue Plasminogen Activator) using this Anti-tPA (Tissue Plasminogen Activator) Antibody, clone GMA-043 validated for use in ELISA & WB.
Research Category
Metabolism
Metabolism
Research Sub Category
Enzymes & Biochemistry
Enzymes & Biochemistry
Quality
routinely evaluated by immunoblot on human tPA
Target description
Mr 63kDa
Physical form
100 µg of protein G purified mouse IgG1 lyophilized from 10 mM NaH2PO4, 0.15 M NaCl, 1.0% mannitol, pH 7.4.
Format: Purified
Protein G Purified
Storage and Stability
stable 2 years at -20°C from date of shipment
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Stella E Tsirka
Biochemical Society transactions, 30(2), 222-225 (2002-05-25)
The tissue plasminogen activator (tPA)/plasmin proteolytic system has been implicated in both physiological and pathological processes in the mammalian brain. The physiological roles include facilitating neurite outgrowth and pathfinding. The pathological role involves mediating a critical step in the progression
Liudi Yao et al.
The Journal of biological chemistry, 297(3), 101096-101096 (2021-08-22)
Idiopathic pulmonary fibrosis (IPF) is the prototypic progressive fibrotic lung disease with a median survival of 2 to 4 years. Injury to and/or dysfunction of the alveolar epithelium is strongly implicated in IPF disease initiation, but the factors that determine whether
Tissue-type plasminogen activator: characteristics, applications and production technology.
Rouf, S A, et al.
Biotechnology Advances, 14, 239-266 (1996)
Liudi Yao et al.
Cell death and differentiation, 26(5), 943-957 (2018-07-28)
The contribution of epithelial-mesenchymal transition (EMT) to human lung fibrogenesis is controversial. Here we provide evidence that ZEB1-mediated EMT in human alveolar epithelial type II (ATII) cells contributes to the development of lung fibrosis by paracrine signalling to underlying fibroblasts.
Falgun Shah et al.
Cell chemical biology, 24(7), 858-869 (2017-07-04)
Cutaneous reactions represent one of the most common adverse drug effects observed in clinical trials leading to substantial compound attrition. Three negative allosteric modulators (NAMs) of metabotropic glutamate receptors (mGluRs), which represent an important target for neurological diseases, developed by
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