05-733
Anti-SETA/CIN85/Ruk/SH3KBPI Antibody, clone 84
clone 84, Upstate®, from mouse
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UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
84, monoclonal
species reactivity
rat, mouse, human
manufacturer/tradename
Upstate®
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... SH3KBP1(30011)
Specificity
SETA
Immunogen
6His and HA tagged fusion protein corresponding to full length rat SETA
Application
Detect SETA/CIN85/Ruk/SH3KBPI using this Anti-SETA/CIN85/Ruk/SH3KBPI Antibody, clone 84 validated for use in IP, WB & IC.
Quality
routinely evaluated by immunoblot on RIPA lysates from NG108-15 cells
Target description
85kDa
Physical form
Format: Purified
Legal Information
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Certificates of Analysis (COA)
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CIN85 associates with endosomal membrane and binds phosphatidic acid.
Jing Zhang, Xiudan Zheng, Xiao Yang, Kan Liao, Jing Zhang, Xiudan Zheng, Xiao Yang, Kan Liao
Cell research null
Susan Finniss et al.
Biochemical and biophysical research communications, 325(1), 174-182 (2004-11-04)
SETA/CIN85/Ruk is a multifunctional adaptor protein involved in signal transduction and attenuation downstream of receptor tyrosine kinases. It has a modular structure, and various isoforms that combine different protein-protein interaction domains have been proposed based on cDNA analysis. As a
B Chen et al.
The Journal of biological chemistry, 275(25), 19275-19281 (2000-06-20)
Expression of the src homology 3 (SH3) domain-containing expressed in tumorigenic astrocytes (SETA) gene is associated with the tumorigenic state in astrocytes. SETA encodes a variety of adapter proteins containing either one or two SH3 domains, as suggested by the
Tom Büchse et al.
Molecular & cellular proteomics : MCP, 10(10), M110-M110 (2011-07-05)
The Cbl-interacting 85-kDa protein (CIN85) plays an important role as a negative regulator of signaling pathways induced by receptor tyrosine kinases. By assembling multiprotein complexes this versatile adaptor enhances receptor tyrosine kinase-activated clathrin-mediated endocytosis and reduces phosphatidylinositol-3-kinase-induced phosphatidylinositol-3,4,5-trisphosphate production. Here
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