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Merck
CN

05-348

ANTI-TAU (MAPT) Antibody

Upstate, mouse monoclonal, 5E2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
5E2, monoclonal
Species reactivity:
bovine, rat, rabbit, mouse, human
Application:
IHC, WB
Citations:
24

Key Documents

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Product Name

Anti-Tau Antibody, clone 5E2, clone 5E2, Upstate®, from mouse

biological source

mouse

antibody form

purified antibody

clone

5E2, monoclonal

species reactivity

bovine, rat, rabbit, mouse, human

manufacturer/tradename

Upstate®

technique(s)

immunohistochemistry: suitable, western blot: suitable

isotype

IgG1

NCBI accession no.

NM_016835

UniProt accession no.

P10636

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

100

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General description

50-70kDa

Immunogen

Fetal heat stable MAPS

Application

Detect Tau using this Anti-Tau Antibody, clone 5E2 validated for use in WB, IH.
Research Category
Neuroscience
Research Sub Category
Apoptosis - Additional

Neurodegenerative Diseases

Biochem/physiol Actions

several parts of Tau protein between 50kDa and 70kDa

Physical form

0.1M Tris-glycine, pH 7.4, containing and 0.05% sodium azide
Format: Purified
Protein G Chromatography

Preparation Note

2 years at -20°C

Analysis Note

routinely evaluated in immunoblot on rat brain preparations

Other Notes

Replaces: MAB10417

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K S Kosik et al.
Neuron, 1(9), 817-825 (1988-11-01)
Tau protein has been shown to be an integral component of Alzheimer paired helical filaments (PHF). However, the extent to which tau is incorporated into PHF has not been clear because the antibodies used to label PHF generally do not
Gennady Ermak et al.
The FEBS journal, 273(10), 2100-2109 (2006-05-03)
The RCAN1 protein (previously called calcipressin 1 or MCIP1) binds to calcineurin, a serine/threonine phosphatase (PP2B), and inhibits its activity. Here we demonstrate that regulated overexpression of an RCAN1 transgene (this gene was previously called DSCR1 or Adapt78) also stimulates
MAP2 and tau segregate into dendritic and axonal domains after the elaboration of morphologically distinct neurites: an immunocytochemical study of cultured rat cerebrum.
Kosik, K S and Finch, E A
The Journal of Neuroscience, 7, 3142-3153 (1987)
W R Markesbery et al.
Neurobiology of aging, 14(4), 303-307 (1993-07-01)
Neuropil threads were quantitated in the neuropil (excluding senile plaques) of the superior frontal gyrus of 6 late stage patients with Alzheimer's disease (AD) and 6 age-matched control subjects using tau immunocytochemistry and computerized morphometric image analysis. The mean percent
Tau epitopes are incorporated into a range of lesions in Alzheimer's disease.
Joachim, C L, et al.
Journal of Neuropathology and Experimental Neurology, 46, 611-622 (1987)
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