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05-23-0600

Sigma-Aldrich

Substance P

Neuropeptide found in high concentrations in the gut.

Synonym(s):

Substance P, Neurokinin P, RPKPQQFFGLM, SP

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About This Item

Empirical Formula (Hill Notation):
C63H98N18O13S
CAS Number:
33507-63-0
Molecular Weight:
1347.63
UNSPSC Code:
12352202
NACRES:
NA.51

Quality Level

100

Assay

≥96% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

color

white

solubility

5% acetic acid: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1

InChI key

ADNPLDHMAVUMIW-CUZNLEPHSA-N

General description

Substance P (SP) is an 11-amino acid neuropeptide belonging to the tachykinin (TAC) family of neuropeptides. It is encoded by the TAC1 gene in the central nervous system (CNS), the peripheral nervous system, and immune cells. Moreover, it serves essential functions in inflammation, angiogenesis, and wound healing. It is also found in high concentrations in the gut. When released from afferent nerves, it causes a neurogenic inflammatory response, including mast cell degranulation. It is known to induce Ca2+ mobilization and reported to activate Goα, Gq/11α, and Gsα subunits in CHO cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils.

Application

Substance P (SP) has been used to enhance the lipid accumulation in 3T3‑L1 cells as they undergo differentiation into adipocytes in the presence of elevated glucose levels.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Substance P receptors
Product does not compete with ATP.
Reversible: no

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Roush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.
Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.
Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.
Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.
Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.
Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.
Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Substance P enhances the activation of AMPK and cellular lipid accumulation in 3T3?L1 cells in response to high levels of glucose
Dubon MJ, et al.
Molecular Medicine Reports, 8048-8054 (2015)
Biochemistry, Substance P
Steven B. Graefe, et al.
StatPearls [Internet] (2020)
Chenyu Yang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(15), 2803-2814 (2023-03-11)
The detection of environmental temperatures is critical for survival, yet inappropriate responses to thermal stimuli can have a negative impact on overall health. The physiological effect of cold is distinct among somatosensory modalities in that it is soothing and analgesic
Wenjie Yu et al.
Developmental cell, 57(18), 2221-2236 (2022-09-16)
Pulmonary neuroendocrine cells (PNECs) are rare airway cells with potential sensory capacity linked to vagal neurons and immune cells. How PNECs sense and respond to external stimuli remains poorly understood. We discovered PNECs located within pig and human submucosal glands
Marta Brzozowska et al.
International journal of molecular sciences, 24(12) (2023-06-28)
Aspirin (ASA) is a popular nonsteroidal anti-inflammatory drug (NSAID), which exerts its therapeutic properties through the inhibition of cyclooxygenase (COX) isoform 2 (COX-2), while the inhibition of COX-1 by ASA results in the formation of gastrointestinal side effects. Due to

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