All Photos(1)
Synonym(s):
BQ-788, Sodium Salt, N- cis-2,6-Dimethylpiperidinocarbonyl-L-γ-MeLeu-D-Trp(MeOCO)-D-Nle-OH, Na
Empirical Formula (Hill Notation):
C34H50N5NaO7
Molecular Weight:
663.78
UNSPSC Code:
12352200
NACRES:
NA.28
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Assay
≥95% (HPLC)
Quality Level
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
color
white to off-white
solubility
0.01% NH4OH: 1 mg/mL
DMSO: 2 mg/mL
methanol: water (3:1): 2 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A highly selective and competitive ETB receptor antagonist (IC50 = 1.2 nM).
Highly selective ETB-receptor antagonist (IC50 = 1.2 nM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
ETB-receptor antagonist
ETB-receptor antagonist
Product does not compete with ATP.
Reversible: no
Target IC50: 1.2 nM as ETB-receptor antagonist
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). DMSO and Methano:H₂O stock solutions are stable for up to 2 months at -20°C.
Other Notes
Okada, M., and Nishikibe, M. 2002. Cardiovasc. Drug Reviews20, 53.
Taniai, H., et al. 2001. Hepatology33, 894.
Fukuroda, T., et al. 1994. Biochem. Biophys. Res. Commun.199, 1461.
Ishikawa, K., et al. 1994. Proc. Natl. Acad. Sci. USA91, 4892.
Taniai, H., et al. 2001. Hepatology33, 894.
Fukuroda, T., et al. 1994. Biochem. Biophys. Res. Commun.199, 1461.
Ishikawa, K., et al. 1994. Proc. Natl. Acad. Sci. USA91, 4892.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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