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Key Documents

05-1362

Sigma-Aldrich

Anti-RING1 Antibody, clone 4D6

clone 4D6, from mouse

Synonym(s):

Polycomb complex protein RING1, ring finger protein 1

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100 μG
¥3,603.64

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Estimated to ship on2025年5月06日Details

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100 μG
¥3,603.64

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

¥3,603.64

Estimated to ship on2025年5月06日Details

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Request a Bulk Order

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

4D6, monoclonal

species reactivity

mouse, human

technique(s)

immunocytochemistry: suitable
western blot: suitable

isotype

IgG2aκ

NCBI accession no.

NP_002922.2

UniProt accession no.

Q06587

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Anti-RING1 Antibody, clone 4D6 clone 4D6, from mouse

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Anti-Bmi-1 Antibody, clone F6, Alexa Fluor™ 647 clone F6, from mouse, ALEXA FLUOR™ 647

05637AF647

Anti-Bmi-1 Antibody, clone F6, Alexa Fluor™ 647

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

antibody form

purified antibody

antibody form

affinity isolated antibody

antibody form

purified antibody

antibody form

purified antibody

clone

4D6, monoclonal

clone

F6, monoclonal

clone

F6, monoclonal

clone

F6, monoclonal

shipped in

wet ice

shipped in

ambient

shipped in

wet ice

shipped in

wet ice

technique(s)

immunocytochemistry: suitable, western blot: suitable

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

immunocytochemistry: suitable

technique(s)

immunocytochemistry: suitable

General description

RING1 belongs to the RING finger family, members of which are characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain.

Specificity

This antibody detects RING1.

Immunogen

GST-tagged recombinant protein corresponding to RING1.

Application

Immunocytochemistry: Representative lot data.
A 1:500 dilution of a previous lot was used in immunocytochemistry on NIH/3T3 and A431 cells.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Use Anti-RING1 Antibody, clone 4D6 (Mouse Monoclonal Antibody) validated in WB, ICC to detect RING1 also known as Polycomb complex protein RING1.

Quality

Evaluated by western blot on HEK293 cell lysate.

Western Blot Analysis: 0.5-2 µg/mL of this antibody detected RING1 in HEK293 cell lysate.

Target description

~42 kDa

Physical form

Format: Purified
Protein G Purified
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8ºC from date of receipt.

Analysis Note

Control
HEK293 cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Christine van de Werken et al.
    Nature communications, 5, 5868-5868 (2014-12-19)
    The different configurations of maternal and paternal chromatin, acquired during oogenesis and spermatogenesis, have to be rearranged after fertilization to form a functional embryonic genome. In the paternal genome, nucleosomal chromatin domains are re-established after the protamine-to-histone exchange. We investigated

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