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Merck
CN

04-973

Anti-CD39 Antibody, clone 5F2

clone 5F2, from mouse

Synonym(s):

ectonucleoside triphosphate diphosphohydrolase 1, ATPDase, ecto-apyrase, NTPDase-1, Ecto-ATP diphosphohydrolase, Lymphoid cell activation antigen, NTPDase 1, Ecto-apyrase, CD39 antigen

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Key Documents

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

5F2, monoclonal

species reactivity

mouse

technique(s)

flow cytometry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_033978

UniProt accession no.

P55772

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Entpd1(12495)

Related Categories

General description

Ectonucleoside triphosphate diphosphohydrolase 1 (NTDase 1 or CD39) belongs to the membrane-bound ecto-nucleoside triphosphates diphosphohydrolase family (E-NTPDases) that are characterized for their ability to hydrolyze nucleoside di- and triphosphates, such as ATP, in the presence of cations, i.e. CA2+ and Mg2+. CD39 is an important membrane protein containing two transmembrane domains and a large NTPDase active, extracellular region containing apyrase conserved regions. It is heavily glycosolated, having six known N-glycosolation sites, and functions on the plasma membrane’s outer surface. CD39 initiates the metabolism, of ATP and ADP to adenosine through a 2-step exzymatic reaction, providing extracellular adenosine for the purpose of regulating various inflammatory endpoints. It is a putative marker for B-cell activation and its expression has also been observed on NK-cells, dendritic cells, T-cells, and vascular endothelial cells. CD39 is a known inhibitor of ADP-induced platelet aggregation and may also play a role in angiogenesis.
~ 100 kDa
It has been published that CD39 shows molecular weights between ~70-100 kDa (Wang, T.F. et al., 1996).

Immunogen

Recombinant protein corresponding to mouse CD39.

Application

This Anti-CD39 Antibody, clone 5F2 is validated for use in FC, WB for the detection of CD39.
Western Blot Analysis: A previous lot was used by an independent laboratory in WB.

Biochem/physiol Actions

This antibody recognizes CD39.

Physical form

Format: Purified

Analysis Note

Evaluated by Flow Cytometry in BALB/c splenocytes.

Flow Cytometry Analysis: 0.1 µg/mL of this antibody detected CD39 in BALB/c splenocytes.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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