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Safety Information

03-34-0001

Sigma-Aldrich

H-Gly-Pro-Arg-Pro-OH

Inhibitor of fibrinogen aggregation and fibrin polymerization.

Synonym(s):

H-Gly-Pro-Arg-Pro-OH

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About This Item

Empirical Formula (Hill Notation):
C18H31N7O5
CAS Number:
67869-62-9
Molecular Weight:
425.48
MDL number:
MFCD00133378
UNSPSC Code:
12352202
NACRES:
NA.32

Quality Level

100

Assay

≥98% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

technique(s)

protein extraction: suitable

solubility

5% acetic acid: 1 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12-,13-/m0/s1

InChI key

WXPZDDCNKXMOMC-AVGNSLFASA-N

General description

Inhibitor of fibrinogen aggregation and fibrin polymerization.

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Standard Handling (A)

Other Notes

Barnard, M.R., et al. 1999. Transfusion39, 73.
Rijkers, D.T., et al. 1998. Thromb. Res. 89, 161.
Achyuthan, K.E., and Dobson, J.V. 1986. Biochim. Biophys. Acta872, 261.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yiyuan Zhang et al.
Thrombosis research, 192, 141-151 (2020-06-02)
Kinase inhibitors can pose bleeding risks as platelet signaling evolves during clotting. Using microfluidics (200 s-1 wall shear rate) to perfuse Factor XIIa-inhibited or thrombin-inhibited whole blood (WB) over collagen ± tissue factor (TF), we explored the potency of the Src family kinase

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