03-32-5032
MMP-2/MMP-7 Substrate, Fluorogenic
Extremely sensitive fluorogenic substrate for matrix metalloproteinases (MMPs).
Synonym(s):
MMP-2/MMP-7 Substrate, Fluorogenic
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About This Item
Empirical Formula (Hill Notation):
C49H68N14O15
Molecular Weight:
1093.15
UNSPSC Code:
12352209
NACRES:
NA.83
Quality Level
Assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated
color
yellow
solubility
20% acetic acid: 1 mg/mL
fluorescence
λex ~325 nm
λem ~393 nm
shipped in
ambient
storage temp.
−20°C
General description
Extremely sensitive fluorogenic substrate for matrix metalloproteinases (MMPs). Suitable for assessment of total activity in crude preparations by continuous assays (kcat/Km = 1.7 x 105 M-1sec-1 for MMP-7 and 6.3 x 105 M-1sec-1 for MMP-2).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Fluorogenic substrate for matrix metalloproteinases (MMPs)
Fluorogenic substrate for matrix metalloproteinases (MMPs)
Product does not compete with ATP.
Reversible: no
kcat/Km = 1.7 x 105 M-1sec-1 for MMP-7 and 6.3 x 105 M⁻¹ sec⁻¹ for MMP-2
Warning
Toxicity: Standard Handling (A)
Sequence
MCA-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH₂ ·TFA [Dpa = N-3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl]
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Knight, C.G., et al. 1992. FEBS Lett. 296, 263.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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