SMC^® Human pTau217 High Sensitivity Immunoassay Kit

pTau217 (phospho-Tau 217) refers to a phosphorylated form of the tau protein at serine 217. This specific phosphorylation event alters tau′s conformation and enhances its propensity to aggregate into neurofibrillary tangles, which are hallmarks of several neurodegenerative diseases. In healthy neurons, tau stabilizes microtubules and facilitates intracellular transport. However, when phosphorylated at S217, tau misfolds and forms toxic aggregates that disrupt microtubule stability and impair neuronal function. Elevated levels of phospho Tau 217 in cerebrospinal fluid (CSF) serve as a sensitive biomarker for Alzheimer′s disease and other tauopathies, correlating with disease progression and cognitive decline. Moreover, pTau217 plays a role in neuroinflammation by activating glial cells, which can exacerbate neuronal injury and promote further neurodegenerative processes.

Alzheimer′s Disease / Aging / Nervous System / Neurodegenerative Diseases / Neuroscience

Although pTau217was detectable in mouse, rat, non-human primate (baboon), cow, and pig samples, the assay has not been verified for these species.

96 well assay

• Sensitivity: LLOQ 1,950 fg/ml* (SMCxPRO^® Instrument)
• Standard Curve Range: 490-500,000 fg/mL
• Intra-assay CV: <15%
• Inter-assay CV: <20%
• Linearity: Serum: 104% Plasma: 111% CSF: 111%
• Recovery: Serum: 102% Plasma: 94% CSF: 86%

*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.

NeuroscienceNeurological DisordersNeurodegenerative DiseasesAlzheimer′s Disease

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SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

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