03-0146-00
SMC® Amyloid Beta 42 High Sensitivity Immunoassay Kit
Used for ultrasensitive quantification of Amyloid Beta 1-42 (Aβ42) in human, rat or mouse plasma or cerebrospinal fluid (CSF)
Synonym(s):
Abeta 1-42 immunoassay kit, Abeta 42 Single Molecule Counting Kit, Abeta 42 immunoassay kit, Abeta 42 ultra-sensitive Immunoassay
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About This Item
Quality Level
product line
SMC®
usage
kit sufficient for 96 wells
species reactivity
human
manufacturer/tradename
SMC®
technique(s)
single molecule counting: suitable
input
serum
plasma
cerebrospinal fluid (CSF)
compatibility
for use with for use with FemtoQuest™ and SMCxPRO® instruments (validated)
shipped in
wet ice
storage temp.
2-8°C
General description
Aβ1-42 plays a critical role in the pathogenesis of Alzheimer′s disease. Elevated levels of Aβ1-42 are associated with the development of amyloid plaques, which can disrupt neuronal function, trigger neuroinflammation, and lead to neuronal cell death. The presence of Aβ1-42 in the cerebrospinal fluid (CSF) is often inversely correlated with cognitive decline, making it a valuable biomarker for early diagnosis and monitoring of Alzheimer′s disease. Understanding the function and implications of Aβ1-42 is essential for developing targeted therapies aimed at reducing amyloid burden and mitigating its detrimental effects on brain health in neurodegenerative conditions.
Application
Biochem/physiol Actions
Features and Benefits
- High Sensitivity Detection: Precisely quantifies Amyloid Beta 1-42 at femtogram/mL levels in plasma or CSF.
- Improved Dynamic Range: Enhanced signal-to-noise ratio with reduced background interference for reliable assay performance.
- User-Friendly Workflow: Utilizes a familiar sandwich immunoassay format while ensuring high sensitivity for Aβ1-42 detection.
- Automation-Ready: Compatible with automated liquid handling systems, reducing manual steps and increasing lab efficiency.
Packaging
Analysis Note
- Sensitivity: LLOQ 980 fg/mL* (SMCxPRO® Instrument
- Standard Curve Range: 244-250,000 fg/mL
- Intra-assay CV: <15%
- Inter-assay CV: <20%
- Linearity: CSF: 100%
- Recovery: Plasma: 94% CSF: 92%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.
Neurological Disorders
Neurodegenerative Diseases
Alzheimer′s Disease
Legal Information
Disclaimer
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation
Target Organs
Respiratory Tract
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Regulatory Information
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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