03-0145-00
SMC® Amyloid Beta 1-40 High Sensitivity Immunoassay Kit
Used for ultrasensitive quantification of Amyloid Beta 1-40 (Aβ40) in human, rat or mouse plasma or cerebrospinal fluid (CSF)
Synonym(s):
Abeta 1-40 immunoassay kit, Abeta 40 Single Molecule Counting kit, Abeta 40 immunoassay kit, Abeta 40 ultra-sensitive immunoassay
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About This Item
Quality Level
usage
kit sufficient for 96 wells
species reactivity
human
manufacturer/tradename
SMC®
assay range
sensitivity: 5.86 pg/mL
(lower limit of quantification)
technique(s)
single molecule counting: suitable
input
plasma (K2 EDTA)
cerebrospinal fluid (CSF)
UniProt accession no.
compatibility
for use with FemtoQuest™ and SMCxPRO® instruments
shipped in
wet ice
General description
Aβ1-40 plays a significant role in the pathophysiology of Alzheimer′s disease. Elevated levels of Aβ1-40 in the brain can contribute to neuroinflammation and neuronal damage, disrupting cell signaling and promoting the formation of amyloid plaques. These plaques are characteristic of AD and are believed to trigger a cascade of neurodegenerative processes, leading to cognitive decline and other symptoms associated with the disease. Understanding the function and implications of Aβ1-40 is essential for developing effective diagnostic tools and therapeutic strategies aimed at mitigating its harmful effects in neurodegenerative conditions.
Application
Biochem/physiol Actions
Features and Benefits
- Exceptional Sensitivity: Detects Amyloid Beta 1-40 at femtogram levels, significantly outperforming conventional ELISA methods.
- Wider Dynamic Range: Minimizes background interference to deliver clearer signals and improved assay reliability.
- Optimized Workflow Efficiency: Automation-compatible reagents streamline lab processes and reduce manual intervention.
- Experienced Technical Support: Supported by skilled field scientists and technical teams with expertise in SMC® assays.
Packaging
Analysis Note
- Sensitivity: LLOQ 5,860 fg/mL* (SMCxPRO® instrument
- Standard Curve Range: 340-350,000 fg/mL
- Intra-assay CV: <15%
- Inter-assay CV: <10%
- Linearity: Plasma: 104% CSF: 109%
- Recovery: Plasma 110% CSF: 100%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.
Legal Information
Disclaimer
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Regulatory Information
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Protocols
To determine protein content, the Warburg-Christian method refers to measuring protein samples at 280 nm using a spectrophotometer.
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