Skip to Content

Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

For important updates on recent policy changes, please click here for more details.

Merck
CN
Compare (4)
Sign Into View Organizational & Contract Pricing
GSK343 ≥98% (HPLC)
Sigma-Aldrich
SML0766
GSK343
GSK503 ≥98% (HPLC)
Sigma-Aldrich
SML2718
GSK503
T3-CLK ≥98% (HPLC)
Sigma-Aldrich
SML2650
T3-CLK
ASS234 ≥98% (HPLC)
Sigma-Aldrich
SML2769
ASS234
≥98% (HPLC)
≥98% (HPLC)
≥98% (HPLC)
≥98% (HPLC)
SML0766-5MG
Please contact Customer Service for Availability
CN¥1,829.10
Pricing and availability is not currently available.
SML2650-5MG
Estimated to ship on May 16, 2025
Details...
CN¥1,085.44
SML2769-5MG
Estimated to ship on May 16, 2025
Details...
CN¥1,087.48

Description

Synonyms
N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide, N-[(6-Methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1-(propan-2-yl)-1H-indazole-4-carboxamide
GSK 503, GSK-503, N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-3-methyl-6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide, N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide
4-(2-Methyl-1-(4-methylpiperazin-1-yl)-1-oxopropan-2-yl)-N-(6-(pyridin-4-yl)imidazo[1,2-a]pyridin-2-yl)benzamide, 4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide, T3
N,1-Dimethyl-5-[3-[1-(phenylmethyl)-4-piperidinyl]propoxy]-N-2-propyn-1-yl-1H-indole-2-methanamine, N-[[5-[3-(1-Benzylpiperidin-4-yl)propoxy]-1-methyl-1H-indol-2-yl]methyl]-N-methyl-2-propyn-1-amine
CAS Number
1346704-33-3
1346572-63-1
2109805-56-1
1334106-34-1
Molecular Formula
Empirical Formula (Hill Notation)
: C31H39N7O2
Empirical Formula (Hill Notation)
: C31H38N6O2
Empirical Formula (Hill Notation)
: C28H30N6O2
Empirical Formula (Hill Notation)
: C29H37N3O
Molecular Weight
: 541.69
Molecular Weight
: 526.67
Molecular Weight
: 482.58
Molecular Weight
: 443.62
MDL Number
MFCD25563250
MFCD28405142
MFCD31689325
Quality Designations
100
100
100
100

Properties

Assay:
≥98% (HPLC)
Assay:
≥98% (HPLC)
Assay:
≥98% (HPLC)
Assay:
≥98% (HPLC)
color:
, white to beige to brown
color:
white to beige
color:
white to beige
color:
white to beige
InChI:
1S/C31H39N7O2/c1-6-7-23-14-21(4)35-31(40)26(23)18-33-30(39)25-15-24(16-28-27(25)19-34-38(28)20(2)3)22-8-9-32-29(17-22)37-12-10-36(5)11-13-37/h8-9,14-17,19-20H,6-7,10-13,18H2,1-5H3,(H,33,39)(H,35,40)
InChI:
1S/C31H38N6O2/c1-19(2)37-18-21(4)29-25(30(38)33-17-26-20(3)13-22(5)34-31(26)39)14-24(15-27(29)37)23-7-8-28(32-16-23)36-11-9-35(6)10-12-36/h7-8,13-16,18-19H,9-12,17H2,1-6H3,(H,33,38)(H,34,39)
InChI:
1S/C28H30N6O2/c1-28(2,27(36)33-16-14-32(3)15-17-33)23-7-4-21(5-8-23)26(35)31-24-19-34-18-22(6-9-25(34)30-24)20-10-12-29-13-11-20/h4-13,18-19H,14-17H2,1-3H3,(H,31,35)
InChI:
InChI key:
ULNXAWLQFZMIHX-UHFFFAOYSA-N
InChI key:
HRDQQHUKUIKFHT-UHFFFAOYSA-N
InChI key:
IEFFSHLHNYVSEF-UHFFFAOYSA-N
InChI key:
ADCBAOTWERXLAP-UHFFFAOYSA-N
form:
powder
form:
powder
form:
powder
form:
powder
SMILES string:
CN(CC1)CCN1C2=NC=CC(C3=CC4=C(C=NN4C(C)C)C(C(NCC5=C(CCC)C=C(C)NC5=O)=O)=C3)=C2
SMILES string:
[nH]1[c](c(c(cc1C)C)CNC(=O)c2c3c([n](cc3C)C(C)C)cc(c2)c4cnc(cc4)N5CCN(CC5)C)=O
SMILES string:
[n]21c(nc(c2)NC(=O)c4ccc(cc4)C(C)(C)C(=O)N5CCN(CC5)C)ccc(c1)c3ccncc3
SMILES string:
CN1C(CN(CC#C)C)=CC2=C1C=CC(OCCCC(CC3)CCN3CC4=CC=CC=C4)=C2
solubility:
DMSO: 15 mg/mL, clear
solubility:
DMSO: 2 mg/mL, clear
solubility:
DMSO: 2 mg/mL, clear (warmed)
solubility:
DMSO: 2 mg/mL, clear
storage temp.:
2-8°C
storage temp.:
2-8°C
storage temp.:
room temp
storage temp.:
2-8°C
Quality Level:
100
Quality Level:
100
Quality Level:
100
Quality Level:
100

Usage and Safety

Application
GSK343 has been used:
  • as an inhibitor of enhancer of zeste homolog 2 (EZH2) to assess the impact of chromatin condensation on cell migration
  • as histone methyl transferase inhibitor, to suppress the Polyandrocarpa misakiensis, mitochondrial non-coding-region (NCR) PmNCR reporter gene expression, facilitated by TC14-3
  • as a supplement in the growth medium to inhibit the generation of H3K27me3 or to inhibit RNA polymerase II
  • as EZH2 inhibitor to treat castration-resistant neuroendocrine prostate cancer (CRPC-NE)

Risk and Safety
Pictograms: GHS07
Exclamation mark
Signal Word:

Warning

Hazard Statements: H302
Precautionary Statements: P264 - P270 - P301 + P312 - P501
Hazard Classifications:

Acute Tox. 4 Oral

Storage Class Code:

11 - Combustible Solids

WGK:

WGK 3

Flash Point(F):

Not applicable

Flash Point(C):

Not applicable

Storage Class Code:

11 - Combustible Solids

WGK:

WGK 3

Flash Point(F):

Not applicable

Flash Point(C):

Not applicable

Storage Class Code:

11 - Combustible Solids

WGK:

WGK 3

Flash Point(F):

Not applicable

Flash Point(C):

Not applicable

Storage Class Code:

11 - Combustible Solids

WGK:

WGK 3