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Sodium bicarbonate powder, BioReagent, suitable for cell culture, suitable for insect cell culture
Sigma-Aldrich
S5761
Sodium bicarbonate
Sodium bicarbonate solution solution (7.5%), sterile-filtered, BioReagent, suitable for cell culture
Sigma-Aldrich
S8761
Sodium bicarbonate solution
Sodium bicarbonate certified reference material, pharmaceutical secondary standard
Supelco
PHR3591
Sodium bicarbonate
Sodium bicarbonate puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.7%
Sigma-Aldrich
31437-M
Sodium bicarbonate
powder, BioReagent, suitable for cell culture, suitable for insect cell culture
solution (7.5%), sterile-filtered, BioReagent, suitable for cell culture
certified reference material, pharmaceutical secondary standard
puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.7%
S5761-500G
Available to ship on April 21, 2025
Details...
CN¥650.82
S8761-100ML
Available to ship on April 21, 2025
Details...
CN¥222.09
PHR3591-3G
Estimated to ship on July 21, 2025
Details...
CN¥1,411.86
Pricing and availability is not currently available.

Description

Synonyms
Sodium hydrogen carbonate, soda bicarbonate
aqueous sodium bicarbonate
Monosodium hydrogen carbonate, Sodium hydrogen carbonate
Sodium hydrogen carbonate
CAS Number
144-55-8
144-55-8
144-55-8
144-55-8
Molecular Formula
Linear Formula
: NaHCO3
Linear Formula
: NaHCO3
Linear Formula
: NaHCO3
Empirical Formula (Hill Notation)
: CHNaO3
Empirical Formula (Hill Notation)
: CHNaO3
Empirical Formula (Hill Notation)
: CHNaO3
Molecular Weight
: 84.01
Molecular Weight
: 84.01
Molecular Weight
: 84.01
MDL Number
MFCD00003528
MFCD00003528
MFCD00003528
MFCD00003528
Quality Designations
300
400
300

Properties

Agency:
Agency:
Agency:
traceable to USP 1613655
Agency:
reag. Ph. Eur.
anion traces:
anion traces:
anion traces:
anion traces:
chloride (Cl-): ≤0.003%
phosphate (PO43-): ≤10 mg/kg
Assay:
99.5-100.5%
Assay:
Assay:
Assay:
≥99.7%
cation traces:
cation traces:
cation traces:
cation traces:
As: ≤0.0002%
Ca: ≤0.01%
Cd: ≤0.0005%
Co: ≤0.005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.005%
Ni: ≤0.005%
Pb: ≤0.0005%
Zn: ≤0.0005%
heavy metals: ≤5 mg/kg (by ICP-OES)
density:
2.16 g/mL at 25 °C (lit.)
density:
density:
2.16 g/mL at 25 °C (lit.)
density:
2.16 g/mL at 25 °C (lit.)
impurities:
impurities:
endotoxin, tested
impurities:
impurities:
≤0.003% S-compounds (as SO4)
≤0.015% in water insoluble matters
≤5 mg/kg ammonium (NH4)
≤50 mg/kg I red. matters (as SO2)
InChI:
1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
InChI:
1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
InChI:
1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
InChI:
1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
InChI key:
UIIMBOGNXHQVGW-UHFFFAOYSA-M
InChI key:
UIIMBOGNXHQVGW-UHFFFAOYSA-M
InChI key:
UIIMBOGNXHQVGW-UHFFFAOYSA-M
InChI key:
UIIMBOGNXHQVGW-UHFFFAOYSA-M
application(s):
application(s):
application(s):
pharmaceutical
application(s):
packaging:
packaging:
packaging:
pkg of 3G
packaging:
pH:
6.8-7.4
pH:
7.8-8.2
pH:
pH:
≤8.6 (20 °C, 5%)
form:
powder
form:
solution (7.5%)
form:
form:
powder
pKa (25 °C):
(1) 6.37, (2) 10.25 (carbonic acid)
pKa (25 °C):
pKa (25 °C):
(1) 6.37, (2) 10.25 (carbonic acid)
pKa (25 °C):
(1) 6.37, (2) 10.25 (carbonic acid)
product line:
BioReagent
product line:
BioReagent
product line:
product line:
grade:
Molecular Biology
grade:
grade:
certified reference material
pharmaceutical secondary standard
grade:
ACS reagent
puriss. p.a.
quality:
300
quality:
quality:
quality:
SMILES string:
[Na+].OC([O-])=O
SMILES string:
[Na+].OC([O-])=O
SMILES string:
[Na+].OC([O-])=O
SMILES string:
[Na+].OC([O-])=O
solubility:
water: soluble 100 mg/mL
solubility:
solubility:
solubility:
H2O: 0.5 g/10 mL, clear, colorless
water: soluble 50 g/L
sterility:
sterility:
sterile-filtered
sterility:
sterility:
storage temp.:
storage temp.:
2-8°C
storage temp.:
2-30°C
storage temp.:
suitability:
suitability:
suitability:
suitability:
complies for appearance of solution
technique(s):
cell culture | insect: suitable
cell culture | mammalian: suitable
technique(s):
cell culture | mammalian: suitable
technique(s):
technique(s):
Quality Level:
300
Quality Level:
400
Quality Level:
300
Quality Level:

Usage and Safety

Application
Sodium bicarbonate has been used:
  • as a component of bovine embryo culture system during in vitro maturation, fertilization, and culture (IVMFC)
  • as a component of a 1:1 mixture of Dulbecco′s modified Eagle′s medium and Ham′s nutrient mixture F-12 during the culture of bovine microvascular endothelial cells
  • as a component of ITS (insulin transferrin and selenite) medium used during the isolation of dopamine neurons from human embryonic stem cells
  • as a component of medium used for cell culture of human embryonic kidney cells
  • as a component of Beltsville thawing solution used for the dilution of semen
Sodium bicarbonate solution has been used:
  • as a component of Hanks′ buffered salt solution (HBSS) and recording medium for culturing of tissue explants from rats or mice
  • as a component of Dulbecco′s modified Eagle′s medium (DMEM) to culture mice tissue explants
  • as a component of Minimum Essential Media (MEM) to study the cytotoxicity against human colorectal adenocarcinoma cells and mammary gland adenocarcinoma
  • to prepare collagen mix droplets for 3D collagen sprouting assay
  • to prepare collagen matrix for rat epidermal keratinocyte (REK) organotypic culture
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Sodium bicarbonate may be used to maintain 7.4pH in Iscove′s modified Dulbecco′s medium for growth of murine hybridoma cell culture. It may be employed as a component of RPMI-1640 liquid medium in a study.
Risk and Safety
Storage Class Code:

11 - Combustible Solids

WGK:

WGK 1

Flash Point(F):

Not applicable

Flash Point(C):

Not applicable

Personal Protective Equipment:

Eyeshields, Gloves, type N95 (US)

Storage Class Code:

12 - Non Combustible Liquids

WGK:

WGK 1

Flash Point(F):

Not applicable

Flash Point(C):

Not applicable

Storage Class Code:

13 - Non Combustible Solids

WGK:

WGK 1

Flash Point(F):

Not applicable

Flash Point(C):

Not applicable

Storage Class Code:

13 - Non Combustible Solids

WGK:

WGK 1

Flash Point(F):

Not applicable

Flash Point(C):

Not applicable