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Z-007

Supelco

Zolpidem phenyl-4-carboxylic acid solution

500 μg/mL in acetonitrile: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

500 μg/mL in acetonitrile: water (1:1)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c3ccc(cc3)C(O)=O

InChI

1S/C19H19N3O3/c1-12-4-9-16-20-18(13-5-7-14(8-6-13)19(24)25)15(22(16)11-12)10-17(23)21(2)3/h4-9,11H,10H2,1-3H3,(H,24,25)

InChI key

FELZONDEFBLTSP-UHFFFAOYSA-N

General description

Zolpidem Phenyl-4-carboxylic acid is the major urinary metabolite of zolpidem, accounting for 51% of an administered dose. Literature references indicate the metabolite can be found in urine for 2-3 days following ingestion of a single therapeutic dose of zolpidem. Zolpidem, marketed as Ambien® or Stilnox®, is a nonbenzodiazepine used for the short-term treatment of insomnia.

Application


  • Pharmacokinetics in forensic contexts: A study demonstrated the simultaneous analysis of Zolpidem and its metabolites, including Zolpidem phenyl-4-carboxylic acid, in postmortem urine, which is critical for forensic toxicology (Yamaguchi et al., 2023).


  • Detection in hair samples: Research developed a sensitive LC-MS/MS method for detecting picogram levels of Zolpidem and its primary metabolites, such as Zolpidem phenyl-4-carboxylic acid, in hair, offering valuable insights for forensic and clinical investigations (Kim et al., 2021).


  • Advanced analytical techniques: The determination of Zolpidem phenyl-4-carboxylic acid and Zolpidem 6-carboxylic acid in hair was achieved using gas chromatography-electron ionization-tandem mass spectrometry, enhancing the capabilities of toxicological analyses (Kwon et al., 2021).


  • Pharmacokinetic profiling: A study on the pharmacokinetics of Zolpidem and Zolpidem phenyl-4-carboxylic acid in oral fluid post administration provided crucial data for understanding drug behavior in therapeutic monitoring (Feng et al., 2019).


  • Forensic case study: An examination of a fatal zolpidem poisoning case highlighted the postmortem distribution and redistribution of Zolpidem and its predominant metabolite, Zolpidem phenyl-4-carboxylic acid, in body fluids and tissues, offering insights for forensic pathology (Hasegawa et al., 2018).


Legal Information

Ambien is a registered trademark of Sanofi S.A.
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Stilnox is a registered trademark of Sanofi S.A.

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

WGK

WGK 2

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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John H Lewis et al.
Journal of analytical toxicology, 31(4), 195-199 (2007-06-09)
Zolpidem is a non-benzodiazepine hypnotic that has been implicated in both drug-facilitated sexual assault and drink spiking. Detection of the drug in urine is extremely difficult because of its extensive metabolism. A method is presented for the detection and quantitation

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