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V-031

Supelco

Vitamin K2 (MK-4) solution

100 μg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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Empirical Formula (Hill Notation):
C31H40O2
CAS Number:
863-61-6
Molecular Weight:
444.65
MDL number:
MFCD00079646
UNSPSC Code:
41116107
PubChem Substance ID:
329828973
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

(Snap-N-Spike®
Snap-N-Shoot®)

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

-45.69 °C (at 1013 hPa)

application(s)

clinical testing
clinical testing

format

single component solution

storage temp.

−70°C

SMILES string

O=C1C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)=C(C)C(C2=CC=CC=C21)=O

InChI

1S/C31H40O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,12,14,16,18-20H,9-11,13,15,17,21H2,1-6H3/b23-14+,24-16+,25-20+

InChI key

DKHGMERMDICWDU-GHDNBGIDSA-N

Related Categories

General description

Vitamin K2 (MK-4) or menaquinone-4 is an essential cofactor for enzymes that activate blood-clotting factors as well as vitamin K-dependent (VKD) proteins involved in bone metabolism, arterial calcification, growth control, and signal transduction.

Application

This certified solution standard is suitable for use as starting material in the preparation of linearity standards, calibrators, or controls in LC-MS/MS vitamin K2 testing applications such as assessment of vitamin K2 deficiency and research of VKD proteins.
Vitamin K2 (MK-4) also known as menaquinone may be used as a certified reference material (CRM) for the determination of the analyte in biological and animal products by high-performance liquid chromatography (HPLC) method.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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V-041

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V-060

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V-042

Vitamin K2 (MK-4)-13C6 solution, 10 μg/mL in acetonitrile, certified reference material, ampule of 1 mL, Cerilliant®

V-090

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Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

WGK

WGK 2

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Regulatory Information

危险化学品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Simultaneous determination of vitamin K1, vitamin K1 2, 3-epoxide and menaquinone-4 in human plasma by high-performance liquid chromatography with fluorimetric detection
Hirauchi K, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 430(3), 21-29 (1988)
Determination of phylloquinone and menaquinones in animal products with fluorescence detection after postcolumn reduction with metallic zinc
Koivu-Tikkanen TJ, et al.
Journal of Agricultural and Food Chemistry, 48(12), 6325-6331 (2000)
Determination of phylloquinone and menaquinone in human milk using high performance liquid chromatography
Isshiki H, et al.
Journal of Dairy Science, 71(3), 627-632 (1988)
Method for the determination of vitamin K homologues in human plasma using high-performance liquid chromatography-tandem mass spectrometry
Suhara Y, et al.
Analytical Chemistry, 77(3), 757-763 (2005)

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