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Safety Information

T-073

Supelco

L-Thyroxine (T4) solution

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

Synonym(s):

L-Thyroxine, 3,3′,5,5″-Tetraiodo-L-thyronine, 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine, T4

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About This Item

Linear Formula:
HOC6H2(I)2OC6H2(I)2CH2CH(NH2)CO2H
CAS Number:
51-48-9
Molecular Weight:
776.87
Beilstein:
2228515
MDL number:
MFCD00002595
UNSPSC Code:
41116107
PubChem Substance ID:
329826617
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

100 μg/mL in methanol with 0.1N NH3

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

223 °C (dec.) (lit.)

application(s)

clinical testing
clinical testing

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This Item
T074T1775T076
L-甲状腺素（T4） 溶液 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

T073

L-甲状腺素（T4） 溶液

3,3′,5-三碘-L-甲状腺原氨酸（T3） 溶液 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

T074

3,3′,5-三碘-L-甲状腺原氨酸（T3） 溶液

L-甲状腺素 powder, BioReagent, suitable for cell culture

T1775

L-甲状腺素

L-甲状腺素-13C6标准液 CRM 溶液 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

T076

L-甲状腺素-13C6标准液 CRM 溶液

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

application(s)

clinical testing
clinical testing

application(s)

clinical testing
clinical testing

application(s)

-

application(s)

clinical testing

format

single component solution

format

single component solution

format

-

format

single component solution

form

liquid

form

liquid

form

powder

form

liquid

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

300

grade

certified reference material

grade

certified reference material

grade

-

grade

certified reference material

General description

Thyroxine or T4 is a thyroid hormone responsible for regulation of the body′s basal metabolic rate and essential for growth, development and heart and nervous system function. Free and total T4 serum levels are measured by LC-MS/MS for determination of hyper- or hypothyroidism as well as for monitoring treatment with synthetic thyroid hormones. Certified Spiking Solutions® are suitable for use in LC-MS/MS testing methods as starting materials in preparation of linearity standards, calibrators, and controls.

Biochem/physiol Actions

L-Thyroxine (T4) and triiodo-L-thyronine (T3) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes,Central nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Regulatory Information

危险化学品
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    R L Sutherland et al.
    The Journal of endocrinology, 65(3), 319-332 (1975-06-01)
    A competitive binding technique is described for the estimation of the thyroxine (T4)-binding properties of serum proteins in dilute blood serum and lymph. When used in conjunction with an assay for total T4 the following parameters can be estimated: the
    Aleid G van Wassenaer et al.
    Clinical endocrinology, 56(5), 621-627 (2002-05-29)
    Thyroid hormone is crucial for brain development during foetal and neonatal life. In very preterm infants, transient low levels of plasma T4 and T3 are commonly found, a phenomenon referred to as transient hypothyroxinaemia of prematurity. We investigated whether breast
    Sonja Heyerdahl et al.
    Thyroid : official journal of the American Thyroid Association, 13(11), 1029-1038 (2003-12-04)
    Neonatal screening programs for congenital hypothyroidism (CH) were initiated in the 1970s to ensure early treatment in order to prevent mental retardation. With screening, developmental prognosis is considerably improved, but follow-up studies still report developmental delay compared to controls. To
    L Ashley Watson et al.
    The Journal of clinical investigation, 123(5), 2049-2063 (2013-04-09)
    Human ATRX mutations are associated with cognitive deficits, developmental abnormalities, and cancer. We show that the Atrx-null embryonic mouse brain accumulates replicative damage at telomeres and pericentromeric heterochromatin, which is exacerbated by loss of p53 and linked to ATM activation.
    Ihor Hrytsiuk et al.
    Archives of pediatrics & adolescent medicine, 156(5), 485-491 (2002-05-01)
    To determine the effect of levothyroxine sodium starting dose on cognitive development, growth, or behavior in children with congenital hypothyroidism identified by neonatal screening. Systematic review of cohort studies. Two analyses were performed: a between-study comparison of mean starting dose
    View All Related Papers

    Articles

    Simultaneous Determination of Free T3 and Free T4 in Serum

    Determination of free thyroid hormones (T3 & T4) in serum by LC-MS/MS following a streamlined 1-hour BioSPME sample preparation.

    Protocols

    Online SPE/LC-MS Method for the Rapid Analysis of Thyroid Hormones in Plasma

    Determination of the thyroid hormones T4, T3 and rT3 from plasma using an Ascentis Express RP-Amide cartridge to trap the analytes, and a Phenyl-Hexyl column to resolve them.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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