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T-068

Supelco

Tilidine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C17H23NO2 · HCl
CAS Number:
27107-79-5
Molecular Weight:
309.83
EC Number:
200-659-6
MDL number:
MFCD01735084
UNSPSC Code:
41116107
PubChem Substance ID:
329826611
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

Cl.CCOC(=O)[C@@]1(CCC=C[C@H]1N(C)C)c2ccccc2

InChI

1S/C17H23NO2.ClH/c1-4-20-16(19)17(14-10-6-5-7-11-14)13-9-8-12-15(17)18(2)3;/h5-8,10-12,15H,4,9,13H2,1-3H3;1H/t15-,17+;/m1./s1

InChI key

MUWDJVKYGSDUSH-KALLACGZSA-N

Related Categories

General description

Tilidine is a synthetic opioid analgesic used mainly in Germany, Switzerland and Belgium for treatment of moderate to severe pain, both acute and chronic. While tilidine is considered a moderately-potent opioid, its active metabolite nortilidine possesses analgesic effects roughly equivalent to that of morphine.

Application

  • Opioid Detection in Hair: Research demonstrated the application of liquid chromatography/tandem mass spectrometry for detecting opioids, including Tilidine, in hair samples from palliative care patients, offering insights into long-term drug use and compliance monitoring (Musshoff et al., 2007).

  • Drug Testing in Hair Analysis: An analytical technique using LC-ESI-MS/MS and MALDI-MS/MS imaging was utilized to distinguish between Tilidine intake and external contamination in segmental hair analysis, improving accuracy in drug testing scenarios (Poetzsch et al., 2015).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Target Organs

Eyes

WGK

WGK 1

Flash Point(F)

49.5 °F

Flash Point(C)

9.7 °C

Regulatory Information

监管及禁止进口产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Christoph Köhler et al.
Analytical and bioanalytical chemistry, 400(1), 17-23 (2010-12-09)
The opioid tilidine is a prodrug which is hepatically metabolized to active nortilidine and bisnortilidine. Due to the increasing abuse of tilidine by drug users and the lack of a specific immunoassay, we developed an analytical method for the quantification
Canli Zhang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 879(22), 2089-2094 (2011-06-21)
We report in this manuscript, the use of direct ammonium persulfate-enhanced chemiluminescence (CL) imaging, to monitor changes to measure serum salbutamol concentration in subjects of different haptoglobin (Hp) phenotypes at different dosing time. It was noted that CL generated from
[The chronic pain patient: assuring long-term success].
Thomas Nolte
Krankenpflege Journal, 43(7-10), 203-203 (2006-03-07)
[The transdermal 7-day buprenorphine patch--an effective and safe treatment option, if tramadol or tilidate/naloxone is insufficient. Results of a non-interventional study].
Ulf Schutter et al.
MMW Fortschritte der Medizin, 152(31-33), 49-49 (2010-09-11)
[Tilidine-Naloxone sustained-release tablets for chronic pain associated with musculoskeletal disease].
U Junker et al.
MMW Fortschritte der Medizin, 148(37), 45-45 (2006-10-14)
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